# Dermatofibrosarcoma protuberans misdiagnosed as lipoma: a case report and literature review

**Authors:** Xinghao Yang, Feiyu Yin, Haiyang Jiang, Yuqin Wang, Longguo Dai, Zhishun Yang, Xusong Pang, Chongjian Zhang

PMC · DOI: 10.3389/fonc.2026.1697836 · Frontiers in Oncology · 2026-03-12

## TL;DR

A rare skin tumor was misdiagnosed as a lipoma, highlighting the need for careful differential diagnosis in soft tissue masses.

## Contribution

This case report adds to the literature on the diagnostic challenges of DFSP in atypical locations.

## Key findings

- DFSP was misdiagnosed as a lipoma due to nonspecific clinical and imaging findings.
- Pathological examination was necessary to confirm the correct diagnosis of DFSP.
- The case underscores the importance of considering DFSP in differential diagnoses of soft tissue masses.

## Abstract

Dermatofibrosarcoma protuberans (DFSP) is a relatively rare locally aggressive skin tumor. In its early stages, it can be easily confused with benign tumors such as lipomas and fibromas. Negative surgical margins represent the preferred treatment method for DFSP. For patients with advanced, unresectable disease, imatinib is a good option. The high rate of local recurrence remains a significant issue affecting patient prognosis. Here, we report on a case of a 30-year-old male patient with DFSP originating from the pubic symphysis. Due to the nonspecific clinical signs and the imaging findings, coupled with the rarity of DFSP and its location, the patient was misdiagnosed as having a lipoma and underwent surgical treatment. It was only through pathological examination that a diagnosis of DFSP was confirmed. This case emphasizes the importance of considering DFSP in the differential diagnosis of soft tissue masses, even in atypical locations.

## Linked entities

- **Diseases:** Dermatofibrosarcoma protuberans (MONDO:0011934), lipoma (MONDO:0005106)

## Full-text entities

- **Diseases:** lipoma (MESH:D008067), skin tumor (MESH:D012878), fibromas (MESH:D005350), soft (MESH:C562950), benign tumors (MESH:D009369), DFSP (MESH:D018223)
- **Chemicals:** imatinib (MESH:D000068877)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13017231/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC13017231/full.md

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Source: https://tomesphere.com/paper/PMC13017231