# Bringing back ‘significance’ to MGUS

**Authors:** Koushan Kouranloo, Pasan Serasinghe, Majid Kazmi, Sajitha Sachchithanantham, Neeraj Kohli, Matthew Streetly, Emma Benton, David D’Cruz

PMC · DOI: 10.1093/rheumatology/keag115 · Rheumatology (Oxford, England) · 2026-03-15

## Full-text entities

- **Genes:** LOC102723407 (immunoglobulin heavy variable 4-38-2-like) [NCBI Gene 102723407] {aka IGHV4, IGHV4-30, IGHV4-38-2, IGHV4-39, IGHV4-b, IGVH4-39}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, PRTN3 (proteinase 3) [NCBI Gene 5657] {aka ACPA, AGP7, C-ANCA, CANCA, MBN, MBT}, MPO (myeloperoxidase) [NCBI Gene 4353]
- **Diseases:** lichen planus (MESH:D008010), bone lesions (MESH:D001847), leukocytoclastic vasculitis (MESH:C535509), ANCA (MESH:D056648), vasculitic infarcts (MESH:D007238), neoplasia (MESH:D009369), peripheral sensory neuropathy (MESH:D010523), ulcer (MESH:D014456), sensory loss (MESH:C580162), autoimmune (MESH:D001327), autoimmune connective tissue disease (MESH:D003240), joint pains (MESH:D018771), organ dysfunction (MESH:D009102), paraneoplastic syndrome (MESH:D010257), Raynaud (MESH:D011928), myeloma (MESH:D009101), cutaneous lesions (MESH:D009059), pruritis (MESH:D011537), Vasculitis (MESH:D014657), IgA MGUS (MESH:D008998), thrombotic (MESH:D013927), inflammatory (MESH:D007249), smoker (MESH:C000719328), urticarial vasculitic lesions (MESH:C535817), Monoclonal Gammopathy (MESH:D010265), G6PD deficiency (MESH:D005955), plasma cell disorders (MESH:D007952), shortness of breath (MESH:D004417), digital (MESH:C000721267), nosebleeds (MESH:D004844), pigmentation (MESH:D010859), hair-loss (MESH:D000505), paraprotein (MESH:C563516), motor deficit (MESH:D009461), pruritic rash (MESH:D005076), hypertension (MESH:D006973)
- **Chemicals:** methotrexate (MESH:D008727), FDG (MESH:D019788), hydroxychloroquine (MESH:D006886), bortezomib (MESH:D000069286), methylprednisolone (MESH:D008775), EuroLupus (-), mycophenolate mofetil (MESH:D009173), colchicine (MESH:D003078), prednisolone (MESH:D011239), Dapsone (MESH:D003622), ciclosporin (MESH:D016572), azathioprine (MESH:D001379), steroid (MESH:D013256), alcohol (MESH:D000438), Congo Red (MESH:D003224), cyclophosphamide (MESH:D003520)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

2 references — full list in the complete paper: https://tomesphere.com/paper/PMC13017004/full.md

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Source: https://tomesphere.com/paper/PMC13017004