# Urinary antigen–negative Legionella pneumonia in critically ill patients: value of systematic molecular testing for optimal antimicrobial therapy

**Authors:** Livia Foglia Manzillo, Maddalena Teggia Droghi, Francesca Iannuzzi, Daniele Castelli, Giuseppe Foti, Paolo Bonfanti, Marco Giani

PMC · DOI: 10.1093/jac/dkag101 · Journal of Antimicrobial Chemotherapy · 2026-03-14

## Full-text entities

- **Genes:** PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) [NCBI Gene 5286] {aka CPK, OCSKD, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, UROD (uroporphyrinogen decarboxylase) [NCBI Gene 7389] {aka PCT, UPD}
- **Diseases:** community-acquired pneumonia (MESH:D003147), respiratory failure (MESH:D012131), Failure (MESH:D051437), Legionella infections (MESH:D007877), infections (MESH:D007239), Legionella pneumonia (MESH:D011014), toxicity (MESH:D064420), critically ill (MESH:D016638), acute (MESH:D000208)
- **Chemicals:** sodium (MESH:D012964), macrolide (MESH:D018942), fluoroquinolone (MESH:D024841), levofloxacin (MESH:D064704), UAT (-), oxygen (MESH:D010100), azithromycin (MESH:D017963), beta-lactam (MESH:D047090), carbapenems (MESH:D015780)
- **Species:** Legionella pneumophila (species) [taxon 446], Legionella pneumophila serogroup 1 (serogroup) [taxon 66976], Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC13016887/full.md

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Source: https://tomesphere.com/paper/PMC13016887