# Dermoscopic Examination of Generalized Lichen Nitidus in a Patient With Down Syndrome

**Authors:** Karina Okamura, Natsuko Aoki, Tomoko Uemura, Mayuko Yamamoto, Kozo Nakai

PMC · DOI: 10.7759/cureus.104140 · Cureus · 2026-02-23

## TL;DR

This paper describes a case where dermoscopy helped diagnose generalized lichen nitidus in a patient with Down syndrome.

## Contribution

The study presents the first description of dermoscopic findings in generalized lichen nitidus in a Down syndrome patient.

## Key findings

- Dermoscopy aided in the accurate clinical diagnosis of generalized lichen nitidus.
- This case highlights the potential utility of dermoscopy in diagnosing skin conditions in individuals with Down syndrome.
- Patients with Down syndrome are prone to various dermatological conditions, including lichen nitidus.

## Abstract

Down syndrome, also known as trisomy 21, is the most frequently identified chromosomal disorder. Patients with Down syndrome frequently present with a broad spectrum of dermatological conditions, including atopic dermatitis, nonspecific dermatitis, folliculitis, seborrheic dermatitis, and cutaneous infections. Several cases of generalized lichen nitidus in individuals with Down syndrome have been reported. However, dermoscopic findings have not been previously described in these cases. We report a case in which dermoscopy contributed significantly to the clinical diagnosis, illustrating its potential role in improving diagnostic accuracy.

## Linked entities

- **Diseases:** Down syndrome (MONDO:0008608), atopic dermatitis (MONDO:0004980), folliculitis (MONDO:0006552), seborrheic dermatitis (MONDO:0006608)

## Full-text entities

- **Diseases:** atopic dermatitis (MESH:D003876), chromosomal disorder (MESH:D025063), Lichen Nitidus (MESH:D017513), Down Syndrome (MESH:D004314), nonspecific dermatitis (MESH:D016585), folliculitis (MESH:D005499), cutaneous infections (MESH:D007239), seborrheic dermatitis (MESH:D012628)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13016861/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC13016861/full.md

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Source: https://tomesphere.com/paper/PMC13016861