# Comparison of long-term patient-reported outcome and quality of life 10 years after severe trauma versus polytrauma

**Authors:** Adelina Denzel, Annette Keß, Christian Kleber, Georg Osterhoff, Pasyodun Koralage Buddhika Mahesh, Pasyodun Koralage Buddhika Mahesh, Pasyodun Koralage Buddhika Mahesh

PMC · DOI: 10.1371/journal.pone.0345816 · PLOS One · 2026-03-25

## TL;DR

This study compares quality of life ten years after severe trauma or polytrauma, finding significant physical impairments in polytrauma patients but similar psychological and social outcomes between groups.

## Contribution

The study provides novel long-term insights into quality of life and functional outcomes in trauma survivors, emphasizing the role of non-physical factors in recovery.

## Key findings

- Polytrauma patients had worse physical impairments and pain compared to severe trauma patients.
- No significant differences were found in psychological or social quality of life between the two groups.
- 60.4% of the cohort reported reduced quality of life ten years post-injury, regardless of injury severity.

## Abstract

Severe trauma and polytrauma are major public health concerns due to their long-term impact on survivors’ quality of life (QoL). While advances in trauma care have improved survival rates, long-term functional, psychological, and social outcomes remain inadequately understood. This study evaluates the health-related quality of life (HRQoL), functional deficits, and mortality of trauma patients ten years post-injury, comparing severely injured (SI) and polytrauma (PT) patients.

Patients admitted to the shock trauma unit at a Level 1 trauma center between 2010 and 2013 with an Injury Severity Score (ISS) ≥ 9 were identified. Survivors were categorized into SI (ISS ≥ 9 and <16 or isolated injury in one body region) and PT (ISS ≥ 16 and injuries in multiple body regions). HRQoL was assessed using the Polytrauma Outcome (POLO) Chart, including the EuroQol 5D-3L, SF-36, and Trauma Outcome Profile (TOP).

Ninety-one patients (42 SI, 49 PT) completed follow-up, with an additional 80 confirmed deceased patients. Polytrauma patients had significantly longer hospital and ICU stays, higher rates of mechanical ventilation, and worse functional outcomes (p < 0.001). While PT patients reported more physical impairments and pain (SF-36 Physical Functioning, Physical Role, and Pain dimensions; p < 0.05), no significant differences were observed in psychological or social dimensions. Overall, 60.4% of the cohort reported reduced QoL (EuroQol Index ≤0.8), with no significant difference between SI and PT groups. Long-term mortality did not differ between groups (p = 0.6).

Ten years post-trauma, both SI and PT patients experience substantial reductions in QoL, with physical impairments more pronounced in PT patients. However, psychological and social outcomes appear independent of injury severity, suggesting that factors beyond trauma severity influence long-term recovery. These findings highlight important associations relevant to long-term outcomes and underscore the need for further research to better define how persistent pain, functional limitations, and psychosocial factors interact in long-term recovery after severe injury and polytrauma.

## Full-text entities

- **Diseases:** head and neck injuries (MESH:D006258), lower extremity fractures (MESH:D010291), AIS (MESH:D013734), Pain (MESH:D010146), occupational injuries (MESH:D060051), psychological disorders (MESH:D000067073), Reduced quality of life (MESH:D001523), Death (MESH:D003643), pelvis (MESH:D010386), Depression (MESH:D003866), articular and shaft injuries (MESH:D000092504), Trauma (MESH:D014947), amputations (MESH:C565682), articular injuries (MESH:D057072), anxiety (MESH:D001007), traumatic brain injuries (MESH:D000070642), functional deficits (MESH:D001289), deficits (MESH:D009461), SI (MESH:D045169), chronic pain (MESH:D059350), PTSD (MESH:D013313), shock (MESH:D012769), POLO (MESH:D009104), traffic accidents (MESH:D000081084)
- **Chemicals:** 5D (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC13016348/full.md

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Source: https://tomesphere.com/paper/PMC13016348