# Cutaneous Paraconiothyrium cyclothyrioides Infection in Lung Transplant Recipient, Georgia, USA

**Authors:** Carolyn Mackey, Stephanie Thomas, Lucy S. Witt, Elizabeth Sajewski, Shawn R. Lockhart, Stephanie M. Pouch, Justin Cheeley, Jamie B. MacKelfresh, Jeremy A.W. Gold

PMC · DOI: 10.3201/eid3203.251042 · 2026-03-01

## TL;DR

A lung transplant recipient in Georgia developed a rare mold infection that was eventually treated with posaconazole after delays.

## Contribution

Reports a rare case of Paraconiothyrium cyclothyrioides infection in a transplant patient and highlights diagnostic and treatment challenges.

## Key findings

- The infection was caused by the rare mold Paraconiothyrium cyclothyrioides.
- Treatment with posaconazole resolved the infection after significant diagnostic delays.
- The case highlights the need for better clinical awareness and diagnostic tools for such infections.

## Abstract

We report a cutaneous infection caused by Paraconiothyrium cyclothyrioides, a rare environmental mold, in a lung transplant recipient in Georgia, USA. The infection resolved with posaconazole after substantial diagnostic delays and related side effects. This case underscores the need for improved clinical awareness, diagnostic testing, treatments, and surveillance for such infections.

## Linked entities

- **Chemicals:** posaconazole (PubChem CID 468595)
- **Diseases:** infection (MONDO:0005550)
- **Species:** Paraconiothyrium cyclothyrioides (taxon 300256)

## Full-text entities

- **Diseases:** Emerging Infections (MESH:D004630), mold diseases (MESH:D004194), fungal disease (MESH:D009181), cutaneous infection (MESH:D007239), idiopathic pulmonary fibrosis (MESH:D054990), invasive mold diseases (MESH:D009361), P. cyclothyrioides infection (MESH:D016720), insomnia (MESH:D007319), skin lesions (MESH:D012871), tremor (MESH:D014202), inflammatory (MESH:D007249), pseudoepitheliomatous hyperplasia (MESH:D006965), fatigue (MESH:D005221), infectious (MESH:D003141)
- **Chemicals:** Periodic (-), Posaconazole (MESH:C101425), itraconazole (MESH:D017964), amphotericin B (MESH:D000666), silver (MESH:D012834), basiliximab (MESH:D000077552), eosin (MESH:D004801), isavuconazole (MESH:C508735), tacrolimus (MESH:D016559), mycophenolate mofetil (MESH:D009173), methenamine (MESH:D008709), prednisone (MESH:D011241), voriconazole (MESH:D065819), Hematoxylin (MESH:D006416)
- **Species:** Paraconiothyrium cyclothyrioides (species) [taxon 300256], Homo sapiens (human, species) [taxon 9606], Fonsecaea (genus) [taxon 40354], Penicillium (genus) [taxon 5073], Aspergillus niger (species) [taxon 5061], Saccharomyces cerevisiae (baker's yeast, species) [taxon 4932]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13016015/full.md

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Source: https://tomesphere.com/paper/PMC13016015