# Rapid Interventions to Limit Outbreak of Invasive Streptococcus pneumoniae in Correctional Facility, North Carolina, USA, 2024

**Authors:** Camden D. Gowler, Emma Doran, Niketa D. Williams, Justin P. Albertson, Ty Lautenschlager, Sopio Chochua, Ryan Gierke, Arthur Campbell, Miwako Kobayashi, Aaron Fleischauer, Erica Wilson

PMC · DOI: 10.3201/eid3203.250789 · 2026-03-01

## TL;DR

A Streptococcus pneumoniae outbreak in a North Carolina prison was controlled through movement restrictions and vaccination, but serotype 4 poses challenges for vaccine effectiveness.

## Contribution

The study demonstrates the effectiveness of rapid interventions in controlling an outbreak of Streptococcus pneumoniae serotype 4 in a correctional facility.

## Key findings

- Movement restrictions and 23-valent pneumococcal vaccination halted new cases of Streptococcus pneumoniae.
- Serotype 4 was identified as a challenge for current vaccination strategies in correctional settings.

## Abstract

A Streptococcus pneumoniae serotype 4 outbreak in a North Carolina correctional facility resulted in 14 cases (8 suspected, 1 probable, and 5 confirmed). After implementation of movement restrictions and vaccination with 23-valent pneumococcal polysaccharide vaccine, new cases ceased. Serotype 4 presence in this setting raises challenges for an effective vaccination strategy.

## Linked entities

- **Species:** Streptococcus pneumoniae (taxon 1313)

## Full-text entities

- **Diseases:** heart, liver, or lung disease (MESH:D008171), infection (MESH:D007239), HIV infection (MESH:D015658), pneumonia (MESH:D011014), death (MESH:D003643), cough (MESH:D003371), IPD (MESH:D011008), sepsis (MESH:D018805), chronic (MESH:D002908)
- **Chemicals:** cefotaxime (MESH:D002439), ceftriaxone (MESH:D002443), polysaccharide (MESH:D011134), cefuroxime (MESH:D002444), clindamycin (MESH:D002981), 23-valent pneumococcal polysaccharide vaccine (-), meropenem (MESH:D000077731), rifampin (MESH:D012293), chloramphenicol (MESH:D002701), azithromycin (MESH:D017963), amoxicillin (MESH:D000658), tetracycline (MESH:D013752), trimethoprim/sulfamethoxazole (MESH:D015662), linezolid (MESH:D000069349), levofloxacin (MESH:D064704), erythromycin (MESH:D004917), doxycycline (MESH:D004318), penicillin (MESH:D010406), vancomycin (MESH:D014640), quinupristin/dalfopristin (MESH:C062940)
- **Species:** Homo sapiens (human, species) [taxon 9606], Streptococcus pneumoniae (species) [taxon 1313]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13016010/full.md

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Source: https://tomesphere.com/paper/PMC13016010