# Mycobacterium riyadhense Pulmonary Disease after Relocation from Saudi Arabia, Japan

**Authors:** Takuya Ozawa, Takeshi Komine, Sohei Nakayama, Yusuke Suzuki, Naoki Hasegawa, Koichi Fukunaga, Ho Namkoong, Hanako Fukano, Takanori Asakura

PMC · DOI: 10.3201/eid3203.251418 · 2026-03-01

## TL;DR

A patient who moved from Saudi Arabia to Japan developed a rare type of lung disease caused by a bacteria likely acquired in Saudi Arabia.

## Contribution

This is the first reported case of Mycobacterium riyadhense pulmonary disease in Japan, highlighting its potential for long-term persistence after relocation.

## Key findings

- The patient's infection was traced to Mycobacterium riyadhense, a species previously reported only in Saudi Arabia.
- Genomic analysis indicated the infection likely originated in Saudi Arabia and was not newly acquired in Japan.
- The case suggests that M. riyadhense can cause pulmonary disease and persist after geographic relocation.

## Abstract

We report a case of Mycobacterium riyadhense pulmonary disease in a patient who relocated from Saudi Arabia to Japan. Epidemiologic data and whole-genome analyses of the isolated strains suggested that the infection might have been acquired in Saudi Arabia and persisted, rather than a recent local acquisition in Japan.

## Linked entities

- **Diseases:** pulmonary disease (MONDO:0005275)
- **Species:** Mycobacterium riyadhense (taxon 486698)

## Full-text entities

- **Diseases:** M. riyadhense infection (MESH:C566367), infection (MESH:D007239), pulmonary deterioration (MESH:D008175), Pulmonary Disease (MESH:D008171), granular opacities (MESH:D003318)
- **Chemicals:** macrolide (MESH:D018942), fluoroquinolone (MESH:D024841), ethambutol (MESH:D004977), rifampin (MESH:D012293), Azithromycin (MESH:D017963)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mycobacterium riyadhense (species) [taxon 486698]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13016003/full.md

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Source: https://tomesphere.com/paper/PMC13016003