Kidney Dysfunction In Young People Living With HIV On Dolutegravir-Based Regimens In Kampala, Uganda

TL;DR

This study examines kidney health in young HIV-positive individuals in Uganda using dolutegravir-based treatments and finds common kidney issues.

Contribution

The study provides new insights into kidney dysfunction among young HIV patients on dolutegravir-based regimens in Uganda.

Findings

Kidney abnormalities were common among participants on dolutegravir-based regimens.

Tenofovir/dolutegravir was associated with higher serum creatinine and lower creatinine-based eGFR.

Longitudinal studies are needed to assess chronic kidney disease risk in this population.

Abstract

We assessed the association between dolutegravir (DTG)-based antiretroviral therapy and kidney abnormalities among young people living with HIV aged 10–24 years in Kampala, Uganda. In this cross-sectional study, albumin-creatinine ratio (ACR), proteinuria, and estimated glomerular filtration rate (eGFR) were measured. Among 483 participants, 78% received tenofovir (TDF)/DTG. Mean serum creatinine was higher and creatinine-based eGFR lower among those on TDF/DTG, while cystatin C and cystatin C-based eGFR were similar. The prevalence of elevated ACR, proteinuria, and eGFR <90 ml/min/1.73m2 was similar. Kidney abnormalities were common, supporting the need for longitudinal studies to clarify chronic kidney disease risk.