# Barriers and Facilitators to Hepatitis C Virus Treatment in Los Angeles County

**Authors:** Shikha Handa, Nathan Sudeep, Larisa Albers, Monica Pattarroyo, Juan Vasquez, Roberto E. Montgomerie, Ryan M. Nguyen, Kendall Dimson, Deena Afana, Chrysovalantis Stafylis, Jeffrey D. Klausner, Daniel Soto

PMC · DOI: 10.21203/rs.3.rs-9025931/v1 · 2026-03-16

## TL;DR

This study explores what stops people in Los Angeles from getting Hepatitis C treatment and what helps them start it, focusing on underserved communities.

## Contribution

The study integrates quantitative and qualitative data to identify both community and individual barriers and facilitators to HCV treatment.

## Key findings

- 54% of participants reported barriers like personal issues, provider challenges, insurance problems, and lack of medical access.
- Homelessness, incarceration, and drug addiction were identified as major personal barriers to treatment.
- Facilitators included personal motivation, family support, trust in providers, and understanding treatment benefits.

## Abstract

Diagnosed but untreated chronic Hepatitis C virus (HCV) infection is a major public health problem in Los Angeles (LA) County, particularly among underserved and minority groups. This mixed-methods study (October 2024-January 2025) used de-identified programmatic data from 344 case-residents in a linkage-to-cure program and conducted thematic analysis of semi-structured interviews with ten participants (seven untreated, three treated) from the linkage-to-cure program. By integrating these quantitative and qualitative findings, the study identified community-level and individual barriers and facilitators to HCV treatment. Quantitatively, 54% of case-residents reported barriers, such as personal barriers, provider-specific barriers, insurance barriers, and inadequate access to medical care. Qualitative themes expanded on these findings, identifying homelessness, incarceration, and drug addiction as key personal barriers. Provider-related barriers included language barriers, frustration in navigating the healthcare system, long wait times to see a provider, and participants’ lack of HCV information. Insurance barriers were characterized by cost barriers and inadequate access to medical care due to a lack of transportation. Facilitators of treatment included personal motivation to seek treatment, family and community-based support systems, trust in their medical provider, adequate insurance coverage, understanding the benefits of HCV treatment, and the desire to avoid stigmatization. Eliminating HCV as a public health problem requires equitable interventions that address individual and system-level barriers. These include implementing language support services, leveraging patient navigation and care coordination services, utilizing mobile clinics for the unhoused, ensuring treatment continuity for people re-entering the community from incarceration, and removing insurance restrictions, such as prior authorization requirements.

## Linked entities

- **Diseases:** Hepatitis C infection (MONDO:0005231)

## Full-text entities

- **Diseases:** drug addiction (MESH:D019966), chronic Hepatitis C virus (HCV) infection (MESH:D019698)
- **Species:** Homo sapiens (human, species) [taxon 9606], Hepatitis C Virus [taxon 11103]

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Source: https://tomesphere.com/paper/PMC13015591