# Sheep blastocyst-like structure models derived from stem cells

**Authors:** Jing Cao, Jie Li, Miaohan Jin, Wenwen Shen, Jie Li, Saizheng Han, Jiqiang Fu, Shengjiao Song, Shenshen Shang, Fei Gao, Bo Liu, Xi Cao, Xiaoyu Niu, Zhen Liu, Xiaolong Wang

PMC · DOI: 10.1038/s41421-026-00872-x · 2026-03-24

## Full-text entities

- **Genes:** HLA-G (major histocompatibility complex, class I, G) [NCBI Gene 3135] {aka MHC-G}, SOX2 [NCBI Gene 101110563], WNT6 (Wnt family member 6) [NCBI Gene 7475], GATA3 (GATA binding protein 3) [NCBI Gene 2625] {aka HDR, HDRS}, DNMT3B [NCBI Gene 106990108], KRT80 [NCBI Gene 101113319], CYP19A1 (cytochrome P450 family 19 subfamily A member 1) [NCBI Gene 1588] {aka ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX}, Akt [NCBI Gene 100294652], GCM1 (GCM transcription factor 1) [NCBI Gene 8521] {aka GCMA, hGCMa}, KRT8 [NCBI Gene 101110495], FGF2 (fibroblast growth factor 2) [NCBI Gene 2247] {aka BFGF, FGF-2, FGFB, HBGF-2}, CDX2 (caudal type homeobox 2) [NCBI Gene 1045] {aka CDX-3, CDX2/AS, CDX3}, KRT7 [NCBI Gene 101112716], GATA6 [NCBI Gene 100820751], NANOG [NCBI Gene 100302345], CHGA (chromogranin A) [NCBI Gene 1113] {aka CGA, PHE5, PHES}, ITGA5 (integrin subunit alpha 5) [NCBI Gene 3678] {aka CD49e, FNRA, VLA-5, VLA5A}, ZO-1 [NCBI Gene 443200], CDH5 (cadherin 5) [NCBI Gene 1003] {aka 7B4, CD144}, SALL4 [NCBI Gene 101119746], CDX2 [NCBI Gene 101112831], ASCL2 (achaete-scute family bHLH transcription factor 2) [NCBI Gene 430] {aka ASH2, HASH2, MASH2, bHLHa45}, GATA3 [NCBI Gene 780483], KRT8 (keratin 8) [NCBI Gene 3856] {aka CARD2, CK-8, CK8, CYK8, K2C8, K8}, SDC1 (syndecan 1) [NCBI Gene 6382] {aka CD138, SDC, SYND1, syndecan}, MMP2 (matrix metallopeptidase 2) [NCBI Gene 4313] {aka CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1}
- **Diseases:** TLC (MESH:D002292), ST (MESH:D000072657), teratoma (MESH:D013724)
- **Chemicals:** H&E (MESH:D006371), CHIR99021 (MESH:C473711), Doxycycline (MESH:D004318), lipid (MESH:D008055), HDM (-)
- **Species:** Ovis aries (domestic sheep, species) [taxon 9940], Homo sapiens (human, species) [taxon 9606], Bos taurus (bovine, species) [taxon 9913], Mus musculus (house mouse, species) [taxon 10090]
- **Cell lines:** HLC — Homo sapiens (Human), Lung adenocarcinoma, Cancer cell line (CVCL_5529), iCDX2- — Homo sapiens (Human), Colon carcinoma, Cancer cell line (CVCL_A628), TE — Oreochromis mossambicus (Mozambique tilapia), Spontaneously immortalized cell line (CVCL_YD05), ESCs — Homo sapiens (Human), Embryonic stem cell (CVCL_UI95), N2B27 — Rattus norvegicus (Rat), Transformed cell line (CVCL_D584), HDM-AC — Mus musculus (Mouse), Mouse leukemia, Cancer cell line (CVCL_F681)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13013973/full.md

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Source: https://tomesphere.com/paper/PMC13013973