# Primary HIV Infection Presenting As Inflammatory Polyradiculopathy Mimicking Guillain-Barré Syndrome: A Case Report

**Authors:** Mohammed Khalid, SureshKumar Rasiah

PMC · DOI: 10.7759/cureus.104087 · 2026-02-22

## TL;DR

A woman with HIV was initially thought to have GBS, showing how HIV can mimic other neurological conditions and the importance of testing.

## Contribution

Highlights the rare presentation of HIV as inflammatory polyradiculopathy and the need for routine HIV testing in unexplained cases.

## Key findings

- HIV can present as inflammatory polyradiculopathy without typical risk factors.
- Routine HIV testing is crucial in unexplained neuromuscular cases.
- Diagnostic challenges exist when HIV mimics Guillain-Barré syndrome.

## Abstract

Primary HIV infection rarely presents with acute neuromuscular weakness. In patients with polyradiculopathy, HIV infection should be considered even in the absence of recognized risk factors. We report a 36-year-old woman with rapidly progressive paraparesis who was initially suspected to have Guillain-Barré syndrome (GBS). Subsequent investigations confirmed an HIV-associated inflammatory polyradiculopathy. This case highlights diagnostic challenges and emphasizes the need for routine HIV testing in unexplained radiculopathies.

## Linked entities

- **Diseases:** Guillain-Barré syndrome (MONDO:0016218)

## Full-text entities

- **Genes:** CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** lower limb weakness (MESH:D018908), pain (MESH:D010146), acute flaccid paralysis (MESH:C000629404), spinal canal stenosis (MESH:D013130), neuropathies (MESH:D009422), sphincter dysfunction (MESH:D046628), CMV (MESH:D003586), inflammatory neuropathies (MESH:D020330), neurological complications (MESH:D002493), varicella zoster virus (MESH:D000073618), post (MESH:D000094025), respiratory tract infection (MESH:D012141), lymphocytic pleocytosis (MESH:D007964), HIV (MESH:D015658), infection (MESH:D007239), hepatitis B infection (MESH:D006509), neuropathic (MESH:D009437), neurosyphilis (MESH:D009494), paraparesis (MESH:D020335), bacterial infection (MESH:D001424), Cauda equina (MESH:D011128), demyelinating (MESH:D003711), Mycobacterium tuberculosis (MESH:D014376), autoimmune neuropathy (MESH:D020274), bladder (MESH:D001745), neurological dysfunction (MESH:D009461), spinal disease (MESH:D013122), reduced appetite (MESH:D001068), lymphadenopathy (MESH:D008206), HIV-associated (MESH:D016263), lower (MESH:D017116), inflammatory radiculopathy (MESH:D011843), TB (MESH:D014390), areflexia (MESH:D000071699), distal symmetric polyneuropathy (MESH:D011115), inflammation (MESH:D007249), CIDP (MESH:D020277), viral (MESH:D014777), neuromuscular weakness (MESH:D009468), lymphomatous meningitis (MESH:D013967), opportunistic infections (MESH:D009894), sensory loss (MESH:C580162), cervical lymphadenopathy (MESH:D002575), metabolic disorders (MESH:D008659), sickle cell disease (MESH:D000755), GBS (MESH:D020275), CD (MESH:D003424), weight loss (MESH:D015431), neoplastic (MESH:D009369)
- **Chemicals:** gadolinium (MESH:D005682), cryptococcal antigen (-), bictegravir/emtricitabine/tenofovir alafenamide (MESH:C000654125), methylprednisolone (MESH:D008775), glucose (MESH:D005947), bilirubin (MESH:D001663)
- **Species:** Homo sapiens (human, species) [taxon 9606], Treponema pallidum (species) [taxon 160], Human immunodeficiency virus 1 (no rank) [taxon 11676], Human alphaherpesvirus 3 (Varicella-zoster virus, no rank) [taxon 10335]

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13013630/full.md

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Source: https://tomesphere.com/paper/PMC13013630