# Research progress on the roles of extracellular vesicles in tumor immunity and drug resistance

**Authors:** Minghong Zhao, Meijin Liu, Wenlong Huang, Haibin Shen, Qing Jin, Tao Qin, Defa Huang

PMC · DOI: 10.3389/fimmu.2026.1750226 · Frontiers in Immunology · 2026-03-11

## TL;DR

This review explores how extracellular vesicles influence tumor immunity and drug resistance, offering insights into their potential as biomarkers and therapeutic targets.

## Contribution

The paper provides a comprehensive overview of recent advances in understanding extracellular vesicles' roles in cancer biology.

## Key findings

- EVs play a key role in immune evasion and tumor progression.
- EVs contribute to the development of resistance to therapeutic agents.
- EVs show potential as diagnostic biomarkers and therapeutic targets.

## Abstract

Extracellular vesicles (EVs) have emerged as pivotal mediators of intercellular communication and have attracted considerable scientific interest in recent years owing to their critical roles in tumor immunity and drug resistance. This review offers a comprehensive overview of the mechanisms by which EVs function within the tumor microenvironment, focusing on their involvement in immune evasion, tumor progression, and the development of resistance to therapeutic agents. By summarizing recent research advances, this review highlights the potential of EVs as diagnostic biomarkers and therapeutic targets and emphasizes their significance in improving treatment efficacy and overcoming clinical resistance. This review also outlines future research directions to clarify the multifaceted roles of EVs in cancer biology and facilitate the development of novel therapeutic approaches to enhance patient outcomes.

## Full-text entities

- **Diseases:** cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13013411/full.md

## References

130 references — full list in the complete paper: https://tomesphere.com/paper/PMC13013411/full.md

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Source: https://tomesphere.com/paper/PMC13013411