# Impact of cricothyroid membrane puncture anesthesia on elderly patients undergoing endotracheal intubation after anesthesia induction: a clinical study

**Authors:** Yanbing Wang, Hongchuan Zhao, Yanjiao Liang, Xiaoli Li, Xiao Bi, Hao Lian

PMC · DOI: 10.3389/fphys.2025.1600369 · Frontiers in Physiology · 2026-03-11

## TL;DR

This study found that using cricothyroid membrane puncture anesthesia in elderly patients during endotracheal intubation helps reduce coughing and improves blood pressure stability without causing more side effects.

## Contribution

The study demonstrates that cricothyroid membrane puncture anesthesia improves hemodynamic stability and reduces coughing in elderly patients during anesthesia.

## Key findings

- CMP anesthesia reduced hypotension and vasoactive drug use in elderly patients.
- CMP anesthesia lowered coughing during extubation in elderly patients.
- Hemodynamic parameters like heart rate and blood pressure were more stable with CMP anesthesia.

## Abstract

This study investigated the clinical effects of cricothyroid membrane puncture (CMP) anesthesia surface anesthesia following anesthesia induction on elderly patients undergoing endotracheal intubation (ETI).

Eighty elderly patients scheduled for general anesthesia with endotracheal intubation at our hospital from January to December 2023 were enrolled and randomly assigned (n = 40 each) to a study group or a control group. After intravenous anesthesia induction, the study group received 2% lidocaine via CMP for surface anesthesia, while the control group received no CMP administration. The incidence of coughing during extubation in the emergence phase, first-attempt intubation success, hypoxemia, hypotension, and vasoactive drug use were recorded. Hemodynamic parameters and adverse events were compared between groups.

All patients achieved successful first-attempt intubation. There were no significant differences in hypoxemia incidence between groups (P > 0.05). The study group had lower rates of hypotension and vasoactive drug use compared with the control group (P < 0.05), as well as a lower incidence of coughing during extubation (P < 0.05). At T0, heart rate (HR), systolic blood pressure (SBP), mean arterial pressure (MAP), and SpO2 did not differ significantly (P > 0.05). At T1-T3, HR, SBP, and MAP were significantly lower in the study group (P < 0.05), with no significant differences in SpO2 (P > 0.05). Total adverse event rates were similar between groups (P > 0.05).

CMP surface anesthesia following anesthesia induction in elderly patients provides favorable clinical effects by improving hemodynamic stability and reducing coughing during emergence, without increasing adverse events.

## Linked entities

- **Chemicals:** lidocaine (PubChem CID 3676)

## Full-text entities

- **Diseases:** hypotension (MESH:D007022), coughing (MESH:D003371), hypoxemia (MESH:D000860)
- **Chemicals:** lidocaine (MESH:D008012), vasoactive drug (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC13012972/full.md

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Source: https://tomesphere.com/paper/PMC13012972