# Outcomes of acute meningitis according to immunosuppression status: 15-year retrospective cohort

## TL;DR

This study examines outcomes of acute meningitis in immunosuppressed and non-immunosuppressed adults over 15 years.

## Contribution

It identifies clinical features and outcomes of acute meningitis in immunosuppressed patients compared to non-immunosuppressed ones.

## Key findings

- Immunosuppressed patients had lower CSF glucose levels and a broader range of causative pathogens.
- Mortality was 20% overall, with age over 50, altered mental status, and bacterial meningitis as independent predictors of death.
- Immunosuppression was not independently associated with in-hospital mortality.

## Abstract

Acute meningitis remains a primary global health concern. Immunosuppressed patients have risks due to atypical clinical presentations and a broader range of causative pathogens. We aimed to describe the outcomes and clinical features of acute meningitis according to immunosuppression status. We performed a retrospective cohort study of adults with acute meningitis from January 2009 to December 2023. Patients with postsurgical meningitis were excluded. Outcomes and demographic, clinical, and laboratory features were compared using non-parametric statistical tests, and mortality was analyzed using multivariate logistic regression. Among 189 patients, 96 (51%) were immunosuppressed. The median age was lower in immunosuppressed patients (36 vs. 50 years, p < 0.01). There were no differences in symptoms; the classical triad was present in only 21% vs. 19%. Immunosuppressed patients had lower CSF glucose levels (59% vs. 39%, p = 0.004). Overall mortality was 20%, with no significant difference by immune status. Independent predictors of death included age over 50 years (OR 2.9), altered mental status (OR 4.7), and bacterial meningitis (OR 2.3). Acute meningitis in immunosuppressed hosts shows attenuated inflammatory CSF profiles and a broader etiologic spectrum. Immunosuppression was not independently associated with in-hospital mortality.