# Emphasizing the O in OPAT: A Pathway for Clinic-Initiated Outpatient Parenteral Antimicrobial Therapy (CI-OPAT) at an Academic Center

**Authors:** Molly McDonough, Michael Yarrington, Jason Funaro, Jenny Shroba, Kristen Dicks

PMC · DOI: 10.1093/ofid/ofag105 · Open Forum Infectious Diseases · 2026-03-03

## TL;DR

This paper describes a successful outpatient program for administering antibiotics that avoids hospital visits and is safe for selected patients.

## Contribution

The paper introduces a clinic-initiated outpatient parenteral antimicrobial therapy program with low complication rates.

## Key findings

- 59 outpatients were treated with CI-OPAT with low complication rates.
- The program successfully avoided unnecessary emergency department visits and inpatient admissions.
- CI-OPAT is shown to be safe and effective for appropriately selected patients.

## Abstract

Our infectious diseases (ID) clinic began a clinic-initiated outpatient parenteral antimicrobial therapy (CI-OPAT) program to avoid unnecessary emergency department visits or inpatient admissions. In this single-center retrospective case series, we describe the treatment of 59 outpatients with CI-OPAT with low rates of complications. These findings suggest that CI-OPAT programs can be safe and effective.

Our infectious diseases clinic implemented a program for clinic-initiated OPAT (CI-OPAT) to avoid unnecessary emergency department visits and inpatient admissions. This single-center retrospective case series describes the treatment of 59 outpatients with CI-OPAT with low rates of complications suggesting that CI-OPAT programs can be safe and effective for appropriately selected patients.

## Full-text entities

- **Diseases:** neurosyphilis (MESH:D009494), CI-OPAT (MESH:D015819), infections (MESH:D007239), deaths (MESH:D003643), bone and joint infections (MESH:D001847), PICCs (MESH:D056824), system (MESH:D015619), ADEs (MESH:D064420), pulmonary (MESH:D008171), hematologic cancer (MESH:D009369), bloodstream infection (MESH:D018805), ID (MESH:D003141), anaphylactic reaction (MESH:D000707), thrombus (MESH:D013927), cerebral abscess (MESH:D001922)
- **Chemicals:** beta-lactams (MESH:D047090), vancomycin (MESH:D014640)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

22 references — full list in the complete paper: https://tomesphere.com/paper/PMC13012596/full.md

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Source: https://tomesphere.com/paper/PMC13012596