# Multilevel associations between skills use, engagement, and treatment outcome in self-guided internet-delivered dialectical behavior therapy for substance use disorders

**Authors:** Danielle Downie, Alexander R. Daros, Chelsey R. Wilks, Lena C. Quilty

PMC · DOI: 10.1371/journal.pmen.0000564 · PLOS Mental Health · 2026-03-24

## TL;DR

This study explores how skills use and engagement in an online therapy program for substance use disorders relate to treatment outcomes.

## Contribution

The study provides preliminary evidence on the role of emotion dysregulation in treatment outcomes for internet-delivered DBT.

## Key findings

- Within-person increases in emotion dysregulation were linked to higher SUD severity and disability.
- DBT skills and mindfulness showed small-medium effects but were not significantly associated with outcomes after correction for multiple tests.
- Treatment engagement indices did not significantly moderate outcomes after correction for multiple tests.

## Abstract

Internet-delivered dialectical behavior therapy (iDBT) represents a scalable and accessible treatment approach for individuals with substance use disorders (SUDs), yet little is known about the mechanisms of change and the role of engagement in this format. This study examined within- and between-person associations between changes in skills-based constructs (mindfulness, DBT skills use, emotion dysregulation) and two treatment outcomes (SUD severity and functional disability) across a 12-week self-guided iDBT program. The moderating role of treatment engagement was also evaluated. 72 participants with past year SUDs were randomized to immediate or delayed iDBT and completed assessments at baseline and weeks 4, 8, and 12. Multilevel models were used to assess within- and between-person associations between skills and outcomes over time. Several indices of engagement were used including treatment acceptability, usability, and hours/days spent on iDBT. Within-person increases in emotion dysregulation were associated with higher SUD severity and disability, over and above respective between-person effects. DBT skills and mindfulness were not significantly associated with outcomes after correction for multiple tests, though the latter produced a small-medium effect size at the between-persons level. There were no significant moderation effects of treatment outcomes after correction for multiple tests, but several produced small-medium effect sizes. These preliminary findings support the role of emotion dysregulation as a key correlate of treatment response and promote further research within an iDBT context. Future work should refine measurement of DBT skill acquisition and investigate longer-term functional impacts of digital DBT interventions.

## Full-text entities

- **Genes:** DBT (dihydrolipoamide branched chain transacylase E2) [NCBI Gene 1629] {aka BCATE2, BCKAD-E2, BCKADE2, BCKDH-E2, BCOADC-E2, E2}
- **Diseases:** Agoraphobia (MESH:D000379), long-term harms (MESH:D000088562), Specific Phobia (MESH:C562465), impaired emotion regulation (MESH:C565631), self-harm (MESH:D012652), Post-Traumatic Stress Disorder (MESH:D013313), Panic Disorder (MESH:D016584), Persistent Depressive Disorder (MESH:D019263), functional (MESH:D003291), impulsive behaviors (MESH:D010554), Bipolar I/II Disorder (MESH:D001714), depression (MESH:D003866), mental health disorders (OMIM:603663), emotion dysregulation (MESH:D021081), BPD (MESH:D001883), trauma (MESH:D014947), anxiety (MESH:D001007), Cannabis Use Disorder (MESH:D002189), Social Anxiety Disorder (MESH:D000072861), distress (MESH:D012128), COVID-19 (MESH:D000086382), suicidal ideation (MESH:D001072), Major Depressive Disorder (MESH:D003865), Nicotine Use Disorder (MESH:D014029), Generalized Anxiety Disorder (MESH:C000726808), psychotic (MESH:D011618), mental health problems (MESH:D000076082), disordered eating (MESH:D001068), Alcohol Use Disorder (MESH:D000437), obsessive-compulsive (MESH:D009771), Substance Use Disorder (MESH:D019966), anxiety disorder (MESH:D001008), Mental Disorders (MESH:D001523)
- **Chemicals:** iDBT (-), alcohol (MESH:D000438), nicotine (MESH:D009538)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13012472/full.md

## References

63 references — full list in the complete paper: https://tomesphere.com/paper/PMC13012472/full.md

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Source: https://tomesphere.com/paper/PMC13012472