# Impact of Physiotherapy Intervention on Pain, Quality of Life, and Function in Low Back Pain Associated With Piriformis Syndrome: Protocol for Systematic Review

**Authors:** Nikita Deshmukh

PMC · DOI: 10.2196/72350 · JMIR Research Protocols · 2026-03-24

## TL;DR

This paper outlines a systematic review protocol to assess how physiotherapy affects pain, function, and quality of life in people with low back pain caused by piriformis syndrome.

## Contribution

The study introduces a structured protocol to evaluate physiotherapy's effectiveness for piriformis syndrome-related low back pain using RCTs.

## Key findings

- The review will analyze RCTs to determine the impact of physiotherapy on pain and function.
- It will focus on quality-of-life improvements in patients with piriformis syndrome.
- Findings will be summarized narratively to highlight effective intervention components.

## Abstract

Piriformis syndrome is a neuromuscular condition with hip and buttock pain and other symptoms, including referred pain towards the lower back and leg and radiating towards the foot’s medial aspect. Similarly, low back pain caused by piriformis syndrome is undetected or difficult to diagnose because of similar symptoms of lumbar disc herniation, lumbar stenosis, or radiculopathy, as well as neurogenic pain. A study conducted in 2013 found 2910 patients experienced low back pain with sciatica, which is the most common cause of low back pain, because of piriformis muscle stiffness. The prevalence of low back pain in piriformis syndrome is 5%‐36%. It is more commonly seen in women than men.

This systematic review protocol seeks to identify evidence whether physiotherapy interventions effectively relieve pain, improve functional outcomes, and enhance quality of life among individuals experiencing low back pain associated with piriformis syndrome.

This review will analyze randomized controlled trials (RCTs) that include physiotherapy for patients with low back pain linked to piriformis syndrome. The included studies must report on pain levels or improvements in function related to quality-of-life outcomes. Searches will take place using Google Scholar, Pubmed/MEDLINE, the Cochrane Library, and PEDro for articles published from January 2014 to January 2025. Two reviewers will individually check the studies, choose relevant ones, and collect data while assessing quality using the Cochrane risk of bias tool. We will provide a narrative summary of the findings, concentrating on data about pain management, functional improvement, and quality of life enhancements.

This review will synthesize knowledge focusing on pain, quality of life and functions in low back pain, which is associated with piriformis syndrome. A synthesis of the findings will be conducted to determine which components of the interventions identified were the most advantageous to the patient population.

The systematic review protocol is designed to identify the effectiveness of physiotherapy interventions for managing low back pain in piriformis syndrome. This analysis will review RCTs with evidence-based recommendations on reducing pain, improving function, and enhancing quality of life.

## Linked entities

- **Diseases:** piriformis syndrome (MONDO:0043320)

## Full-text entities

- **Diseases:** hip pathologies (MESH:D025981), irritation of the sciatic nerve (MESH:D020426), lumbar radiculopathy (MESH:D011843), sciatica (MESH:D012585), numbness (MESH:D006987), inflammation (MESH:D007249), peripheral neuritis (MESH:D009443), Degenerative disc disease (MESH:D055959), nerve (MESH:C537568), stenosis (MESH:D003251), intervertebral disc herniation (MESH:D007405), muscle weakness (MESH:D018908), Pain (MESH:D010146), muscle stiffness (MESH:D019042), Low back pain (MESH:D017116), Sacroiliitis (MESH:D058566), fatigue (MESH:D005221), spondylolysis (MESH:D013169), lumbar stenosis (MESH:C563613), muscle spasm (MESH:D013035), cerebral palsy (MESH:D002547), muscle tenderness (MESH:D063806), overload (MESH:D019190), somatic dysfunction (MESH:D013001), lower-extremity nerve-related symptoms (MESH:D012816), lumbar disc herniation (MESH:C535531), hyperesthesia (MESH:D006941), sacro-iliac joint fracture (MESH:D017543), Sacroiliac joint dysfunction (MESH:C563037), neuromuscular condition (MESH:D009468), PS (MESH:D055958), injuries (MESH:D014947), compression (MESH:D009408), overuse (MESH:D012090)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC13012218/full.md

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Source: https://tomesphere.com/paper/PMC13012218