# Revisiting the link between NADPH oxidase p22phox C242T polymorphism and ischemic stroke risk: an updated meta-analysis

## TL;DR

This study finds no significant link between a genetic variation in NADPH oxidase p22phox and the risk of ischemic stroke.

## Contribution

An updated meta-analysis clarifies the inconsistent findings regarding the C242T polymorphism and ischemic stroke risk.

## Key findings

- No significant association was found between the C242T polymorphism and ischemic stroke susceptibility.
- Subgroup analyses by ethnicity and stroke type also showed no significant risk increase.
- Sensitivity analysis confirmed the stability of the results.

## Abstract

The relationship between the NADPH oxidase p22phox C242T and susceptibility to ischemic stroke (IS) has been extensively studied, yet the findings from these studies remain inconsistent. To clarify this association, we conducted an updated meta-analysis of case-control studies. A comprehensive literature search of PubMed, Embase, and CNKI was performed on January 31, 2025. Studies exhibiting Hardy-Weinberg equilibrium (HWE) deviations in the control population were excluded from analysis. Pooled odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were calculated to evaluate the association across various genetic models. Our meta-analysis included 10 studies, comprising 3,422 cases and 3,410 controls. We found no significant association between the C242T polymorphism and IS susceptibility under any genetic model. Subgroup analyses stratified by ethnicity and IS type similarly revealed no significant increase in risk. Sensitivity analysis confirmed the stability of these pooled results. This updated meta-analysis suggests that the NADPH oxidase p22phox C242T polymorphism lacks a significant association with ischemic stroke risk. Nevertheless, larger and more diverse population studies are warranted to confirm these findings.