# Hypertension and brain damage: evidence from rodent models

## TL;DR

This review explores how hypertension causes brain damage using rodent models and highlights potential treatments.

## Contribution

The paper synthesizes findings from rodent models to clarify hypertension's role in brain damage and treatment options.

## Key findings

- Rodent models like SHR and SHR-SP show cerebrovascular changes linked to hypertension.
- Antihypertensive treatments targeting the renin-angiotensin system may reduce brain damage.
- Hypertension is connected to blood-brain barrier disruption and neuroinflammation.

## Abstract

Hypertension is a prevalent condition that significantly raises the incidence of cerebrovascular and cognitive disorders. This review focuses on the factors most closely linked to stroke, cognitive impairment, and Alzheimer’s disease. Research into pathophysiology and treatment of hypertensive brain damage has greatly benefited from rodent models, which have been crucial in uncovering the underlying mechanisms and developing effective therapeutic strategies. Rodent models, particularly spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHR-SP), have been essential in elucidating the pathophysiological mechanisms connecting hypertension to brain damage. These models exhibit structural and functional cerebrovascular alterations, including blood-brain barrier disruption, microvascular rarefaction, and neuroinflammation. Interventions targeting the renin-angiotensin system have shown promise in mitigating these adverse effects. This review synthesizes current findings from rodent studies, underscoring the pivotal impact of hypertension in brain pathology and the potential therapeutic benefits of antihypertensive treatments.