# Exercise training preferentially modulates α1D-adrenergic receptor expression in peripheral arteries of hypertensive rats

## TL;DR

Exercise training in hypertensive rats mainly affects α1D-adrenergic receptors in peripheral arteries, potentially improving blood pressure and vascular function.

## Contribution

The study reveals that exercise preferentially modulates α1D-adrenergic receptor expression in peripheral arteries of hypertensive rats.

## Key findings

- Exercise training significantly reduced systolic blood pressure in hypertensive rats.
- α1D receptor expression increased in the caudal artery of exercised hypertensive rats.
- P2X1 receptors remained dominant in peripheral arteries after exercise, possibly aiding blood redistribution.

## Abstract

To evaluate the relative expression of α1D, P2X1, and P2Y6 receptor mRNAs in arterial tissues (renal artery [RA], thoracic aorta [Aor], and caudal artery [Cau]) of spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and to assess exercise-induced changes, SHR and WKY rats were assigned to sedentary (S) or exercise training (E) groups. The E group underwent 16 weeks of treadmill training. Systolic blood pressure (SBP) decreased significantly in SHR-E rats. Receptor mRNA expression followed P2X1 > α1D > P2Y6, with P2X1 highest in the Cau and α1D highest in the Aor. SHR rats showed lower expression in all arteries compared to WKY. Exercise training had a greater effect on α1D receptors, while P2X1 remained predominant. In SHR-E rats, expression decreased for all receptors except α1D in the Cau, which increased. The distribution of α1D and P2X1 receptors correlates with vascular diameter and hypertension. Exercise impacts α1D receptors more, particularly in peripheral arteries. P2X1 dominance in peripheral arteries persists post-exercise, possibly aiding blood redistribution during exercise and maintaining organ function.