# Tideglusib accelerates bone–tendon interface healing and improves mechanical strength in a rabbit rotator cuff tear model: an experimental study

## TL;DR

Tideglusib improves healing and strength at the bone-tendon interface in a rabbit model of rotator cuff injury.

## Contribution

This study demonstrates that tideglusib enhances tendon-bone healing biomechanically and histologically in a rabbit model.

## Key findings

- Tideglusib-treated rabbits showed significantly higher load-to-failure values compared to controls.
- Histological evaluation revealed improved cellular organization and tissue healing in the tideglusib group.

## Abstract

The present study aimed to investigate the effects of the glycogen synthase kinase-3 (GSK-3) inhibitor tideglusib on bone-tendon interface healing in a rabbit model of rotator cuff injury, based on biomechanical and histological assessments.

Fourteen New Zealand rabbits underwent supraspinatus tendon detachment to establish a chronic rotator cuff tear model. After six weeks, surgical repair was performed. In the right shoulders, tideglusib was administered at the bone-tendon junction prior to performing the primary repair (drug group), whereas the left shoulders underwent primary repair without biological augmentation (control group). Seven animals were included in the group subjected to biomechanical tension testing, and six for histological evaluation.

Biomechanical evaluation demonstrated that the tideglusib group showed significantly higher load-to-failure values compared with the control group the control group (p < 0.05), whereas elongation at failure showed no statistically significant difference. Histological scoring demonstrated significantly improved cellular organization and tissue healing in the tideglusib group (p < 0.05).

Local application of tideglusib positively enhances tendon–bone healing both biomechanically and histologically. Further studies are warranted to explore its potential clinical applications.