# Pulmonary embolism and aseptic meningitis complicating IVIG for common variable immunodeficiency syndrome

**Authors:** Daniel Butz, Arun Adlakha

PMC · DOI: 10.1016/j.jacig.2026.100666 · 2026-02-13

## TL;DR

A patient with an immune disorder experienced serious side effects from a treatment, showing the need for careful monitoring and adjustments.

## Contribution

The paper introduces a multifaceted management approach to handle complications from IVIG in immunodeficiency patients.

## Key findings

- Patients with common variable immunodeficiency can experience severe adverse events from IVIG.
- Modifying the product, infusion rate, and premedication can help manage these complications effectively.

## Abstract

This case highlights the importance of vigilance for both thrombotic and inflammatory adverse events in patients with common variable immunodeficiency who are receiving intravenous immunoglobulin. It demonstrates that a multifaceted approach, including altering the product, infusion rate, and premedication, can effectively manage these complex complications.

## Linked entities

- **Diseases:** common variable immunodeficiency (MONDO:0015517), pulmonary embolism (MONDO:0005279), aseptic meningitis (MONDO:0006662)

## Full-text entities

- **Diseases:** immunodeficiency (MESH:D007153), thrombotic (MESH:D013927), inflammatory (MESH:D007249), aseptic meningitis (MESH:D008582), Pulmonary embolism (MESH:D011655)
- **Species:** Homo sapiens (human, species) [taxon 9606]

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Source: https://tomesphere.com/paper/PMC13011185