# In rabbits with cheyletiellosis is topical selamectin or injectable ivermectin a more effective treatment?

## TL;DR

Both topical selamectin and injectable ivermectin are safe and effective for treating cheyletiellosis in rabbits, with no significant difference in effectiveness.

## Contribution

The study clarifies that both treatments are equally effective, guiding veterinarians on treatment options based on availability and licensing.

## Key findings

- Topical selamectin and injectable ivermectin are both safe and effective for treating cheyletiellosis in rabbits.
- There is no significant difference in the effectiveness of the two treatments.
- Veterinarians should consider licensed products and client preferences when choosing a treatment.

## Abstract

In rabbits with cheyletiellosis is topical selamectin or injectable ivermectin a more effective treatment?

Treatment.

One paper directly answered the PICO question, a retrospective clinical design study, and was critically reviewed.

Strong.

Both topical selamectin and injectable ivermectin are safe and effective in treating cheyletiellosis. There is no significant difference in the effectiveness of both drugs in treating the infestation.

In pet rabbits with Cheyletiella parasitivorax infestations both topical selamectin and injectable ivermectin have been recognised to be a safe and effective treatment. There is currently insufficient evidence that one is more effective than the other and therefore veterinarians should consider their own clinical experience, client preference and use the licensed product first (in the UK, ivermectin (Xeno, Dechra) spot-on). However, this Knowledge Summary does not comment on the effectiveness of topical ivermectin in treating cheyletiellosis. If injectable ivermectin is not available, topical selamectin can be used under the cascade as an alternative treatment, as it is licensed for the same indication in dogs and cats.