# Juvenile idiopathic arthritis-associated RIG-I S144F variant inhibits type I interferon signaling by blocking TRIM25-mediated ubiquitination

**Authors:** Li Zhang, Song Zhang, Yaoyao Shangguan, Wanming Huang, Haolan Jin, Lili Li, Yuyin Qi, Yuxia Zhang, Ping Zeng, Huifang Xian

PMC · DOI: 10.1016/j.gendis.2025.101791 · 2025-08-07

## Full-text entities

- **Genes:** RIGI (RNA sensor RIG-I) [NCBI Gene 23586] {aka DDX58, RIG-I, RIG1, RLR-1, SGMRT2}, TRIM25 (tripartite motif containing 25) [NCBI Gene 7706] {aka EFP, RNF147, Z147, ZNF147}
- **Diseases:** idiopathic arthritis (MESH:D001168)
- **Mutations:** S144F

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13011034/full.md

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Source: https://tomesphere.com/paper/PMC13011034