# Arctigenin derivative (ARC-18) improved mitochondrial dysfunction and ameliorated frataxin deficiency symptoms via PGC-1α signaling

**Authors:** Qichao Gong, Xiao Han, Tiansu Liu, Bocheng Xiong, Bingge Zhang, Yongmei Xie, Huali Wan, Tahir Ali, Xifei Yang, Shupeng Li

PMC · DOI: 10.1016/j.gendis.2025.101838 · 2025-09-01

## Full-text entities

- **Genes:** PPARGC1A (PPARG coactivator 1 alpha) [NCBI Gene 10891] {aka LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A}
- **Diseases:** frataxin deficiency (MESH:D005621), mitochondrial dysfunction (MESH:D028361)
- **Chemicals:** ARC-18 (-), Arctigenin (MESH:C071942)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13011025/full.md

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Source: https://tomesphere.com/paper/PMC13011025