# UCH-L1 down-regulates HER2 expression and increases lapatinib sensitivity by interacting with HSP90 in HER2-positive breast cancer

**Authors:** Min Zheng, Xisha Chen, Wenqiang Gan, Lei Hou, Zhongmei Zhou, Ceshi Chen, Zhenzhen Liu, Yan Cheng

PMC · DOI: 10.1016/j.gendis.2025.101952 · 2025-11-24

## Full-text entities

- **Genes:** ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, UCHL1 (ubiquitin C-terminal hydrolase L1) [NCBI Gene 7345] {aka HEL-117, HEL-S-53, NDGOA, PARK5, PGP 9.5, PGP9.5}, HSP90AA1 (heat shock protein 90 alpha family class A member 1) [NCBI Gene 3320] {aka EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N}
- **Diseases:** breast cancer (MESH:D001943)
- **Chemicals:** lapatinib (MESH:D000077341)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC13011018/full.md

---
Source: https://tomesphere.com/paper/PMC13011018