# Creutzfeldt–Jakob Disease: Spectrum of Symptoms, Clinical Progress and Diagnostics—Report of Five Cases

## TL;DR

This paper discusses the symptoms, progression, and diagnosis of Creutzfeldt–Jakob disease, a rare and fatal brain disorder, through five case reports.

## Contribution

The paper provides a clinical overview and highlights diagnostic challenges and warning signs for Creutzfeldt–Jakob disease.

## Key findings

- The paper presents five cases to illustrate the spectrum of symptoms and clinical progression of CJD.
- It identifies common diagnostic traps and warning signs for clinicians to consider.
- The study emphasizes the importance of thorough evaluation when CJD symptoms are suspected.

## Abstract

Creutzfeldt–Jakob disease (CJD) is a rare, fatal prion disease of the central nervous system that develops due to the conversion of the normal cellular protein PrPc to the abnormal PrPSc molecule. The first clinical cases were described in the 1920s. The aim of this paper is to present the clinical progress of the disease and the diagnostic process, including some of the most common diagnostic traps. The paper highlights a range of symptoms that should serve as a potential warning signal for clinicians—not just neurologists—indicating the need to evaluate the patient more thoroughly.