# Environmental Determinants of Pediatric Obesity: An Epidemiological Review

**Authors:** Doha Hassan, Mostafa Salama, Reham Ahmed, Seema Kumar

PMC · DOI: 10.3390/epidemiologia7020036 · 2026-03-02

## TL;DR

This paper reviews environmental factors contributing to rising childhood obesity rates and highlights disparities among disadvantaged communities.

## Contribution

The paper provides a comprehensive review of environmental determinants of pediatric obesity and identifies research gaps for targeted interventions.

## Key findings

- Environmental factors like food access and socioeconomic context strongly influence childhood obesity.
- Disadvantaged communities face higher obesity risks due to clustered environmental stressors.
- Interventions must address multiple sectors to effectively combat rising obesity rates.

## Abstract

Pediatric obesity represents an urgent public health concern, with rapidly increasing prevalence across all regions. While genetic susceptibility contributes significantly to interindividual variability in weight, the significant increase in obesity prevalence over the last 30 years is driven by shifts in environmental contributors. This narrative review will summarize evidence on the major environmental determinants of childhood obesity. Environmental contributors to obesity include the food environment, physical activity and built environments, socioeconomic and community context, home and family environments, digital exposures, early life and chemical obesogens and policy drivers. These environmental factors influence activity patterns, dietary habits, sleep, and stress. Additionally, many of these contributing factors cluster within communities that are disadvantaged, thereby increasing predisposition of specific racial, ethnic and socioeconomic groups to childhood obesity. We highlight research gaps and opportunities for multisectoral interventions aligned to impact the growing prevalence of childhood obesity.

## Linked entities

- **Diseases:** obesity (MONDO:0011122)

## Full-text entities

- **Genes:** PFAS (phosphoribosylformylglycinamidine synthase) [NCBI Gene 5198] {aka FGAMS, FGAR-AT, FGARAT, GATD8, PURL}, MC4R (melanocortin 4 receptor) [NCBI Gene 4160] {aka BMIQ20}, PPARG (peroxisome proliferator activated receptor gamma) [NCBI Gene 5468] {aka CIMT1, FPLD3, GLM1, NR1C3, PPARG1, PPARG2}, FTO (FTO alpha-ketoglutarate dependent dioxygenase) [NCBI Gene 79068] {aka ALKBH9, BMIQ14, GDFD, IFEX9}
- **Diseases:** adiposity (MESH:D018205), inflammation (MESH:D007249), gestational diabetes (MESH:D016640), childhood obesity (MESH:D063766), steatotic liver disease (MESH:D008107), impulsive eating (MESH:D001068), hypertension (MESH:D006973), physical (MESH:D059445), Overweight (MESH:D050177), excessive weight gain (MESH:D015430), metabolic diseases (MESH:D008659), , emotional abuse and neglect (MESH:D058069), TS (MESH:D005879), DOHaD (OMIM:603663), BMI (MESH:C536030), Inadequate sleep (MESH:D012892), Endocrine Disruptors (MESH:D004700), Food insecurity (MESH:D005517), Short sleep (MESH:D012893), abdominal obesity (MESH:D056128), abuse (MESH:D019966), cardiovascular disease (MESH:D002318), Obesity (MESH:D009765), type 2 diabetes (MESH:D003924), injury to (MESH:D014947), infections (MESH:D007239), stroke (MESH:D020521), dyslipidemia (MESH:D050171), binge eating (MESH:D002032)
- **Chemicals:** water (MESH:D014867), sugar- (MESH:D000073893), lead (MESH:D007854), NO2 (MESH:D009585), salt (MESH:D012492), organophosphates (MESH:D010755), phthalates (MESH:C032279), BPA (MESH:C006780), EDCs (MESH:C024565), per- and polyfluoroalkyl substances (MESH:D005466), nitrogen oxides (MESH:D009589), Heavy metals (MESH:D019216), PM1 (MESH:C102203), Parabens (MESH:D010226), NOx (-), SSB (MESH:C016118), cadmium (MESH:D002104), cortisol (MESH:D006854)
- **Species:** Bifidobacterium (genus) [taxon 1678], Homo sapiens (human, species) [taxon 9606], gut metagenome (species) [taxon 749906]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13010671/full.md

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Source: https://tomesphere.com/paper/PMC13010671