# Depression and anxiety symptoms in internally migrated women and men after the German unification: Baseline results from the German National Cohort Study (NAKO)

**Authors:** D. Otten, C. Kasinger, L. Kriechel, A.N. Tibubos, K. Berger, G. Schomerus, T. McLaren, M.E. Beutel, S. Speerforck, E. Brähler, Heiko Becher, Heiko Becher, Patricia Bohmann, Hermann Brenner, Stefanie Castell, Daniela Fuhr, Hans J. Grabe, Karin Halina Greiser, Volker Harth, Antje Hebestreit, Jana-Kristin Heise, Stefanie Jaskulski, André Karch, Thomas Keil, Jasmin Kiekert, Lilian Krist, Lena Koch-Gallenkamp, Oliver Kuß, Berit Lange, Michael Leitzmann, Janka Massag, Claudia Meinke-Franze, Rafael Mikolajczyk, Nadia Obi, Annette Peters, Tobias Pischon, Tamara Schikowski, Börge Schmidt, Carsten Oliver Schmidt, Matthias Schulze, Ilais Moreno Velásquez, Kerstin Wirkner

PMC · DOI: 10.1016/j.jmh.2026.100403 · 2026-02-26

## TL;DR

The study found that internal migration in Germany has a minimal impact on mental health differences between East and West Germany.

## Contribution

The study provides empirical evidence that internal migration alone is not a significant factor in mental health differences.

## Key findings

- Effect sizes for mental health differences between internal migrant groups were extremely small.
- East-West migrants reported slightly lower depression and anxiety symptoms than West-East migrants.
- Internal migration explained less than 0.2% of the variance in depression and anxiety symptoms.

## Abstract

•Internal German migrants differ from each other regarding sociodemography.•Differences between internal migrant groups regarding mental health are negligible.•Substantial heterogeneity within migration groups may dilute average differences.•Internal migration alone no substantial factor in explaining mental health differences.•Alignment regarding mental health between East- and West Germany.

Internal German migrants differ from each other regarding sociodemography.

Differences between internal migrant groups regarding mental health are negligible.

Substantial heterogeneity within migration groups may dilute average differences.

Internal migration alone no substantial factor in explaining mental health differences.

Alignment regarding mental health between East- and West Germany.

Background: Internal migration is a special case in Germany, with its history of two formerly divided and re-unified states. In this study, we examined mental health of women and men who migrated internally after the German reunification and compared them with each other and with the non-migrated population in Eastern and Western Germany.

Methods: Baseline data of 161,795 participants (49.9 % women; internal migrants East-West = 7160 [4.4 %] and West-East = 3966 [2.5 %]) from the population-based German National Cohort were used. Internal migration was measured using information on previous (1988) and current residency. To assess mental health (i.e., current depression and anxiety symptoms), the Depression Module of the Patient Health Questionnaire (PHQ-9) and the Generalised Anxiety Disorder Symptoms Scale (GAD-7) were applied. Group differences were assessed using analyses of covariance and Tukey’s Tests. Strengths of effects were tested using omega squared.

Results: Significant differences in levels of current depression and anxiety symptoms between the four groups were found for both women and men, but effect sizes were extremely small (ω² ≈ 0.000–0.002). East-West migrants reported slightly lower current depression symptoms (adj. Mwomen = 4.00, adj. Mmen = 3.17) than West-East migrants (adj. Mwomen = 4.48, adj. Mmen = 3.69). For East-West migrated men the same was found for anxiety symptoms (adj. M = 2.52 versus adj. M = 2.96). Mental health of internal migrants was not better compared to their non-migrated counterparts.

Conclusion: Subgroup analyses revealed group differences to depend on sex, but show negligible effect sizes, with internal migration only explaining less than 0.2 % of the variance for depression and anxiety symptoms. Internal migration alone is thus no substantial factor in explaining mental health differences. Future studies should use longitudinal data to determine temporal associations between internal migration and mental health.

## Linked entities

- **Diseases:** depression (MONDO:0002050), anxiety (MONDO:0005618)

## Full-text entities

- **Diseases:** Anxiety Disorder (MESH:D001008), Depression (MESH:D003866)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13010428/full.md

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Source: https://tomesphere.com/paper/PMC13010428