# CuCl-Promoted β‑Acylation of Cyclopropanols with Thioesters

## TL;DR

This paper introduces a new copper chloride-promoted chemical reaction that efficiently produces 1,4-dicarbonyl compounds from cyclopropanols and thioesters.

## Contribution

The study presents a novel CuCl-promoted β-acylation method with high selectivity and yield for synthesizing 1,4-dicarbonyl compounds.

## Key findings

- A variety of cyclopropanols and thioesters successfully underwent CuCl-promoted β-acylation.
- The mechanism involves Cu(I)-homoenolate reacting with thioester via oxidative addition.
- The method offers high chemoselectivity, regioselectivity, and good to excellent yields.

## Abstract

CuCl-induced cyclopropyl alcohol ring-opening followed
by β-acylation
with thioester is reported. Cyclopropanols and thioesters with various
substitution patterns were successfully subjected to the reaction,
and a series of 1,4-dicarbonyl compounds were synthesized. The mechanistic
investigation revealed the involvement of Cu­(I)-homoenolate, which
reacts with the thioester via oxidative addition. Both experimental
and computational evidence were found. Operational simplicity, high
chemo- and regioselectivity, and good to excellent yields are the
core features of the presented approach.