# Importance of early postoperative mobilization: comprehensive review

**Authors:** Abdulaziz Alsuwaylihi, Dominic O’Connor, Girish P Joshi, Henrik Kehlet, Dileep N Lobo

PMC · DOI: 10.1093/bjsopen/zrag016 · 2026-03-24

## TL;DR

This review examines how early movement after surgery improves recovery, reduces complications, and shortens hospital stays, though evidence varies across different surgical fields.

## Contribution

The paper provides a comprehensive review of the physiological and clinical benefits of early postoperative mobilization and highlights gaps in current evidence.

## Key findings

- Early mobilization reduces hospital length of stay by up to 34% in some surgical populations.
- Prolonged postoperative bed rest increases the risk of postoperative pulmonary complications and pneumonia.
- Evidence on the impact of early mobilization on morbidity and mortality remains inconsistent.

## Abstract

Early postoperative mobilization is an important component of enhanced recovery after surgery protocols, which aim to improve postoperative outcomes. This narrative review explores the historical evolution, physiological impact, and clinical advantages of early postoperative mobilization.

The Embase, MEDLINE, and PubMed databases were searched, without time restrictions, for studies related to postoperative immobilization and mobilization. Randomized clinical trials, observational studies, systematic reviews, meta-analyses, and clinical guidelines pertaining to adult surgical patients were reviewed, aiming to summarize the historical background, the pathophysiology of immobilization, the clinical outcomes of early postoperative mobilization, anaesthetic aspects, adverse events, limitations of the current evidence, and key barriers.

Extended postoperative immobilization was consistently linked with negative physiological outcomes, including muscle atrophy, insulin resistance, venous thromboembolism, and postoperative pulmonary complications. Several studies indicated that each additional day of postoperative bed rest was associated with a nearly threefold increase in the risk of postoperative pulmonary complications, and remaining on bed rest for more than 3 days was associated with a 2.7-fold higher risk of postoperative pneumonia. Conversely, early postoperative mobilization was associated with shorter hospital length of stay, with reductions of up to 34% reported in some surgical populations, and improved functional recovery. However, the effects of early postoperative mobilization on morbidity, quality of life, and mortality were inconsistent across studies.

Early postoperative mobilization provides significant functional and physiological advantages. However, the strength of evidence supporting its impact on clinical outcomes varies according to surgical subspecialities. To improve implementation and reinforce evidence-based recommendations, future research should focus on standardized definitions of early postoperative mobilization, consistent outcome measures, and higher-quality, subspeciality-specific studies.

This narrative review explores the historical evolution, physiological impact, and clinical advantages of early postoperative mobilization. Early mobilization has been associated with reduced hospital length of stay, lower postoperative pain scores, fewer complications, and better functional recovery. However, the recent evidence regarding the impact of early mobilization on postoperative complications and overall clinical outcomes is inconsistent.

## Full-text entities

- **Genes:** GCG (glucagon) [NCBI Gene 2641] {aka GLP-1, GLP1, GLP2, GRPP}, INS (insulin) [NCBI Gene 3630] {aka IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10}, GH1 (growth hormone 1) [NCBI Gene 2688] {aka GH, GH-N, GHB5, GHN, IGHD1A, IGHD1B}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, AVP (arginine vasopressin) [NCBI Gene 551] {aka ADH, ARVP, AVP-NPII, AVRP, VP}, PDK4 (pyruvate dehydrogenase kinase 4) [NCBI Gene 5166], IL6 (interleukin 6) [NCBI Gene 3569] {aka BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2}
- **Diseases:** hypercoagulability (MESH:D019851), complications (MESH:D008107), diarrhoea (MESH:D003967), thromboembolic (MESH:D013923), Postoperative delirium (MESH:D000071257), appetite loss (MESH:D001068), autonomic dysfunction (MESH:D001342), fatigue (MESH:D005221), motor dysfunction (MESH:D000068079), ovarian cancer (MESH:D010051), vomiting (MESH:D014839), muscle and joint stiffness (MESH:C535724), fractures (MESH:D050723), thrombosis (MESH:D013927), inflammatory (MESH:D007249), musculoskeletal complications (MESH:D009140), metabolic dysfunction (MESH:D008659), motion sickness (MESH:D009041), pulmonary resection (MESH:D000072662), venous stasis (MESH:D054070), chronic illness (MESH:D002908), Orthostatic intolerance (MESH:D054971), pulmonary embolism (MESH:D011655), insomnia (MESH:D007319), deterioration of pulmonary function (MESH:D055371), functional disability (MESH:D003291), abdominal cancer (MESH:D009369), weakness (MESH:D018908), critically ill (MESH:D016638), Pain (MESH:D010146), muscle (MESH:D019042), pulmonary, musculoskeletal, metabolic, and cardiovascular complications (MESH:D002318), endothelial (MESH:D005642), sleep disturbances (MESH:D012893), cognitive dysfunction (MESH:D003072), Muscle atrophy (MESH:D009133), osteopenia (MESH:D001851), postoperative pain (MESH:D010149), postoperative nausea and vomiting (MESH:D020250), bladder cancer (MESH:D001749), VTE (MESH:D054556), DVT (MESH:D020246), frailty (MESH:D000073496), knee arthroplasty (MESH:D007718), Pulmonary complications (MESH:D008171), haemodynamic instability (MESH:D043171), shortness of breath (MESH:D004417), tachycardia (MESH:D013610), colorectal (MESH:D015179), bone demineralization (MESH:D018488), atelectasis (MESH:D001261), Disuse muscle atrophy (MESH:D020966), pruritus (MESH:D011537), Metabolic dysregulation (MESH:D021081), lack of muscle contraction (MESH:C536214), dizziness (MESH:D004244), syncope (MESH:D013575), urinary retention (MESH:D016055), injuries (MESH:D014947), sympathetic blockade (MESH:D006732)
- **Chemicals:** aldosterone (MESH:D000450), carbohydrate (MESH:D002241), water (MESH:D014867), bupivacaine (MESH:D002045), nitrogen (MESH:D009584), glucose (MESH:D005947), magnesium (MESH:D008274), CHO (MESH:C034482), morphine (MESH:D009020), dexmedetomidine (MESH:D020927), midazolam (MESH:D008874), dexamethasone (MESH:D003907), lipid (MESH:D008055), adrenaline (MESH:D004837), fat (MESH:D005223), paracetamol (MESH:D000082), cortisol (MESH:D006854), PEP (-), oxygen (MESH:D010100)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** K00414X

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13010080/full.md

---
Source: https://tomesphere.com/paper/PMC13010080