# Precision percutaneous coronary intervention **Authors:** Travis M. Wilson, Uzair Munaf, Nafhat Shaikh, Affan Rizwan, Riyan Siddiqui, Hafeez Ul Hassan Virk, Mahboob Alam, Umair Khalid, Muzamil Khawaja, Tanawat Attachaipanich, Larisa H. Cavallari, Tania Ahuja, Michael G. Nanna, Samin K. Sharma, Lloyd W. Klein, Gary S. Mintz, Chayakrit Krittanawong PMC · DOI: 10.1038/s44325-026-00111-y · 2026-03-23 ## TL;DR This paper discusses how precision-based PCI improves outcomes by using advanced strategies before, during, and after the procedure. ## Contribution The paper highlights the integration of precision strategies in PCI to enhance outcomes and reduce complications. ## Key findings - Precision PCI strategies reduce adverse events and improve procedural efficiency. - Artificial intelligence and pharmacogenomics may enhance personalization in PCI. - Clinical utility of AI and pharmacogenomics in PCI is still in early development. ## Abstract Precision-based percutaneous coronary intervention (PCI) integrates contemporary strategies across the pre-, intra-, and post-procedural phases to improve outcomes and minimize complications. Emerging evidence underscores the value of these strategies in reducing adverse events and improving procedural efficiency. While artificial intelligence and pharmacogenomics hold long-term promise for enhancing personalization, their clinical utility in PCI remains in the early stages of development. ## Full-text entities - **Genes:** CYP2C19 (cytochrome P450 family 2 subfamily C member 19) [NCBI Gene 1557] {aka CPCJ, CYP2C, CYPIIC17, CYPIIC19, P450C2C, P450IIC19}, F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}, P2RY12 (purinergic receptor P2Y12) [NCBI Gene 64805] {aka ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC)}, ADRA2A (adrenoceptor alpha 2A) [NCBI Gene 150] {aka ADRA2, ADRA2R, ADRAR, ALPHA2AAR, FPLD8} - **Diseases:** disease (MESH:D004194), SDD (MESH:D019522), gastrointestinal bleeding (MESH:D006471), persistent (MESH:D000088562), intracranial hemorrhage (MESH:D020300), radial artery spasm (MESH:D020301), spasm (MESH:D013035), aspiration (MESH:D011015), Heart Disease (MESH:D006331), death (MESH:D003643), impaired renal function (MESH:D007674), Refractory Angina (MESH:D000069279), flow-limiting (MESH:D054318), vascular complication (MESH:D003925), stroke (MESH:D020521), TLR (MESH:D009059), ACS (MESH:D054058), arterial disease (MESH:D002539), pseudoaneurysms (MESH:D017541), Bifurcation lesions (MESH:C537283), intimal (MESH:C563733), Bleeding (MESH:D006470), atherosclerosis (MESH:D050197), frailty (MESH:D000073496), arteriovenous fistula (MESH:D001164), ischemia (MESH:D007511), RHD (MESH:D020141), cardiac arrest (MESH:D006323), small vessel disease (MESH:D059345), ST Elevation Myocardial Infarction (MESH:D000072657), CAD (MESH:D003324), pain (MESH:D010146), critically ill (MESH:D016638), luminal stenosis (MESH:D003251), CVD (MESH:D002318), hematoma (MESH:D006406), Coronary Sinus (MESH:D003323), anemia (MESH:D000740), cardiogenic shock (MESH:D012770), reduced renal function (MESH:D001523), nausea, vomiting (MESH:D020250), coronary disease (MESH:D003327), ISR (MESH:D023903), AKI (MESH:D058186), Ischemic (MESH:D002545), AF (MESH:D001281), vessel occlusion (MESH:C536223), coronary spasm (MESH:D003329), CTO (MESH:D001157), Acute Myocardial Infarction (MESH:D009203), cardiac and cerebrovascular (MESH:D002561), CAD stenosis (MESH:D023921), angina (MESH:D000787), SCAD (MESH:C565153), anxiety (MESH:D001007), fibroatheroma (MESH:D058226), neointimal hyperplasia (MESH:D006965), thrombocytopenia (MESH:D013921), TLF (MESH:D051437), unprotected left (MESH:D018487) - **Chemicals:** sirolimus (MESH:D020123), paclitaxel (MESH:D017239), dabigatran (MESH:D000069604), nicardipine (MESH:D009529), Calcium (MESH:D002118), diamond (MESH:D018130), lidocaine (MESH:D008012), nitrate (MESH:D009566), -Molecular-Weight Heparin (-), polymer (MESH:D011108), benzodiazepines (MESH:D001569), lipid (MESH:D008055), metoclopramide (MESH:D008787), Heparin (MESH:D006493), midazolam (MESH:D008874), Fentanyl (MESH:D005283), CS (MESH:D002586), ISDN (MESH:D007548), LMWH (MESH:D006495), aspirin (MESH:D001241), Dexmedetomidine (MESH:D020927), stainless steel (MESH:D013193), furosemide (MESH:D005665), nitroglycerin (MESH:D005996), morphine (MESH:D009020), idarucizumab (MESH:C000594745), Ticagrelor (MESH:D000077486), Everolimus (MESH:D000068338), Clopidogrel (MESH:D000077144), Enoxaparin (MESH:D017984), verapamil (MESH:D014700), prasugrel (MESH:D000068799), apixaban (MESH:C522181), edoxaban (MESH:C552171), rivaroxaban (MESH:D000069552), diazepam (MESH:D003975) - **Species:** Homo sapiens (human, species) [taxon 9606] - **Mutations:** C1291G ## Figures 3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13009385/full.md --- Source: https://tomesphere.com/paper/PMC13009385