Microstructural variation of hippocampal substructures across childhood and adolescence quantified with high-gradient diffusion MRI
Bradley G. Karat, Sila Genc, Erika P. Raven, Marco Palombo, Ali R. Khan, Derek K. Jones
TL;DR
This study uses advanced MRI to track changes in the hippocampus during childhood and adolescence, revealing age-related differences in brain microstructure.
Contribution
The study introduces high-gradient diffusion MRI and SANDI modeling to quantify hippocampal microstructural development in children and adolescents.
Findings
Hippocampal volume, gyrification, and thickness remain stable during childhood and adolescence.
Age-related changes in MR-derived neurite and soma parameters are correlated with adult microstructure markers like myelin and iron content.
Distinct age-related profiles of hippocampal substructures are revealed using high-gradient diffusion MRI.
Abstract
The hippocampus plays a crucial role in cognition, yet its microstructural development during childhood and adolescence remains poorly understood. Here, we investigate age-related differences in hippocampal microstructure using diffusion MRI with ultra-strong gradients (300 mT/m) in a cohort of 88 participants aged 8–19 years. Surface-based hippocampal modelling was combined with established microstructural approaches, and a more advanced biophysical model (Soma and Neurite Density Imaging: SANDI) suited for studying cortical microstructure. Hippocampal volume, gyrification, and thickness remained stable across this developmental window, however we observed significant differences across age related to MR-derived neurite and soma parameters. Diffusion-derived changes across age were found to be correlated with adult microstructure maps related to myelin and iron content, synaptic…
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Taxonomy
TopicsAdvanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Neurogenesis and neuroplasticity mechanisms