# Analysis of factors associated with cervical cancer and precancerous lesions

**Authors:** Danhong Hu, Yin Zhao, Mengnan Han, Weiwei Qian, Xiangqian Xu, Shaoqin Sheng

PMC · DOI: 10.1038/s41598-025-32215-3 · 2026-03-09

## TL;DR

This study finds that cervical cancer and precancerous lesions are linked to HPV infection and the number of deliveries, but not to age or other lifestyle factors.

## Contribution

The study identifies specific risk factors for cervical lesions using clinical data from nearly 3,000 patients.

## Key findings

- Cervical lesions are significantly associated with HPV infection and number of deliveries.
- Age, number of pregnancies, abortions, condom use, and smoking are not significantly linked to cervical lesions.
- Preventive measures targeting HPV and reproductive history could reduce cervical disease incidence.

## Abstract

To investigate factors influencing cervical cancer and precancerous lesions by collecting and analyzing clinical data and pathological results from 2,998 patients undergoing cervical biopsy; Pathological results and clinical data of 2,998 patients who underwent cervical biopsy at the gynecology outpatient clinic of a tertiary hospital in Hangzhou (January 2022–January 2023) were collected. Univariate analysis and multivariate unconditional logistic regression models were used to analyze relevant influencing factors; The results of univariate and multivariate analyses showed that cervical lesions were related to Human Papillomavirus (HPV) infection and the number of deliveries (P < 0.05) but were not related to age, number of pregnancies, number of abortions, use of condoms for contraception, and smoking (P > 0.05); Cervical cancer and precancerous lesions are associated with HPV infection and number of deliveries. It is imperative to implement a series of prevention and treatment measures to inhibit the onset and progression of cervical diseases, thereby reducing their incidence and mortality rates.

## Linked entities

- **Diseases:** cervical cancer (MONDO:0002974)

## Full-text entities

- **Diseases:** cervical diseases (MESH:D002575), HPV infection (MESH:D030361), Cervical cancer (MESH:D002583), precancerous lesions (MESH:D011230)
- **Species:** Human papillomavirus (species) [taxon 10566], Homo sapiens (human, species) [taxon 9606]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13009180/full.md

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Source: https://tomesphere.com/paper/PMC13009180