OPM-based fetal magnetocardiography: fetal cardiac time intervals in healthy pregnancies compared to postnatal ECGs

TL;DR

This study compares fetal heart measurements using a new OPM-based system with postnatal ECGs, showing consistency and potential for detecting heart issues in fetuses.

Contribution

First comparison of fetal cardiac intervals measured by OPM-based fMCG with postnatal ECGs, establishing prediction intervals for normal fetuses.

Findings

OPM-based fMCG results were consistent with previous SQUID-based measurements and postnatal ECG data.

P, PR, and QRS intervals increased with gestational age, but QT and QTc intervals did not.

Postnatal ECGs showed increased P-wave, QRS, and QTc durations compared to fetal measurements.

Abstract

Fetal magnetocardiography (fMCG) is the most accurate method to assess fetal heart rhythm and conduction. New quantum sensor technology makes it possible to use less expensive devices. The aim of the study is to measure cardiac time intervals of healthy fetuses with a new technology, optically pumped magnetometry (OPM), and compare these results with conventional SQUID-based fMCG and postnatal ECGs.

The recordings were made using an OPM-based fMCG system and a person-sized magnetic shield, established at German Heart Center,TUM University, Munich, Germany. The subjects were 57 healthy women with uncomplicated singleton pregnancies, studied at a mean gestational age of 32 ± 3.7 weeks with an overall range of 25–40 weeks. The P, PR, QRS, QT, QTc, and RR intervals were measured and compared with published data from previous fMCG devices and postnatal ECG.

The P, PR, and QRS intervals increased with gestational age, but the QT and QTc intervals did not. The measured values of the OPM device were consistent with those from previously published data SQUID values. U-waves were seen in 17.3% of subjects. Eleven subjects were studied by fMCG after 30 weeks’ gestation and by ECG within 17 weeks of birth. In this cohort, the P-wave duration, QRS duration, and QTc increased after birth, but the PR and QT intervals did not.

The results obtained with our innovative OPM-based fMCG system are comparable to previously available measurements obtained by other technologies. The data establish prediction intervals for OPM-based fMCG waveforms in normal fetuses, which is essential for future clinical application. The technology can be used to recognize fetuses with rhythm or conduction abnormalities that might not be evident by echocardiography. To our knowledge, this is the first report comparing fetal cardiac time intervals measured by OPM-based fMCG with postnatal ECG. Lengthening of cardiac intervals consistent with increased chamber size was seen postnatally.

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