# Clinical application of the REVEAL™ fluorescence loupe in oral lesion assessment: a five-case clinical note

## TL;DR

The REVEAL™ fluorescence loupe helps identify oral lesion types by their autofluorescence patterns, but it should be used alongside traditional biopsies.

## Contribution

Demonstrates the practical use of the REVEAL™ fluorescence loupe in assessing oral lesions in a clinical setting.

## Key findings

- Inflammatory lesions showed bright red autofluorescence, while actinic cheilitis showed heterogeneous brownish and whitish patterns.
- Squamous cell carcinomas lacked significant autofluorescence contrast, and biofilm was marked by an orange signal.
- The device is useful as an adjunct but not a replacement for biopsy in diagnosing oral lesions.

## Abstract

To illustrate the clinical use and feasibility of the REVEAL™ fluorescence loupe as an adjunctive tool in the chairside assessment of inflammatory, potentially malignant, and malignant oral lesions.

Five patients with oral lesions were clinically examined under natural light and with the REVEAL™ loupe. When indicated, biopsy and histopathological analysis were performed

Inflammatory lesions exhibited a bright and homogeneous red autofluorescence pattern. Actinic cheilitis demonstrated heterogeneous brownish autofluorescence with whitish areas. Squamous cell carcinomas did not show significant autofluorescence contrast. The presence of biofilm was highlighted by a distinct orange signal.

The REVEAL™ loupe may support the clinical assessment of oral lesions by illustrating autofluorescence patterns associated with underlying tissue changes. However, its use should be considered complementary to biopsy, not a diagnostic substitute.