# Tamoxifen therapy in juvenile gigantomastia associated with PASH: a case report

## TL;DR

A 10-year-old girl with gigantomastia and PASH showed improvement with tamoxifen therapy, suggesting it as a non-surgical treatment option.

## Contribution

This case report introduces tamoxifen as a potential non-surgical treatment for hormonally driven pediatric gigantomastia associated with PASH.

## Key findings

- Tamoxifen therapy arrested breast growth and resolved inflammatory symptoms in a child with gigantomastia and PASH.
- The case suggests tamoxifen may be an effective non-surgical treatment for hormonally driven pediatric gigantomastia.
- PASH was identified as a secondary inflammatory complication of rapid breast enlargement in this patient.

## Abstract

Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign breast lesion in children. We report a 10-year-old girl with hormonally driven gigantomastia and recurrent mastitis, interpreted as a secondary inflammatory complication of rapid breast enlargement. Treatment with oral tamoxifen led to arrest of breast growth and resolution of inflammatory symptoms. This case supports tamoxifen as a potential non-surgical option for hormonally driven pediatric gigantomastia associated with PASH.