# The Acute Effect of Methylphenidate Ingestion in a Visuomotor Task at Absolute Power Alpha in Healthy Subjects

## TL;DR

This study shows how methylphenidate affects brain activity in healthy people during a task that requires both movement and attention.

## Contribution

The paper introduces a new method to study how methylphenidate modulates frontal alpha brain waves during combined motor and cognitive tasks.

## Key findings

- Methylphenidate altered typical alpha desynchronization in right frontal brain regions during a visuomotor task.
- A single dose of methylphenidate promoted sustained cortical activation in healthy subjects.
- The study provides a sensitive tool for investigating motor-cognitive coupling effects.

## Abstract

Methylphenidate (MPH) is a psychostimulant widely used to enhance attention and executive functions through increased dopaminergic and noradrenergic transmission. Although its effects on cognitive performance are well documented, its acute influence on cortical oscillatory activity, particularly α power, during tasks requiring simultaneous motor and cognitive processing remains poorly understood in healthy adults.

To investigate the acute effects of 10 mg MPH on absolute α power (8–12 Hz) in frontal regions during a visuomotor task in healthy subjects.

A total of 13 right-handed healthy adults (7 men; age 25.6 ± 4.5 years) participated in a randomized, double-blind, placebo-controlled, crossover study. A 20-channel electroencephalography (EEG) was recorded before and after execution of the MIRA visuomotor task (joystick response when a moving target crosses a previously memorized position) under placebo and MPH (10 mg) conditions, with sessions 1 week apart. Absolute α power was compared using two-way ANOVA (condition vs. moment: pre- vs. post-joystick press), followed by paired
t
-tests when appropriate.

Significant condition versus moment interactions were observed at F3 (
p
 = 0.006), F4 (
p
 = 0.003), and F8 (
p
 = 0.023). The main effects of condition and/or moment occurred at Fp1, Fp2, and Fz (all
p
 < 0.05). The use of MPH attenuated or reversed the typical task-related α desynchronization seen under placebo, especially in right frontal regions.

A single 10 mg dose of MPH homogeneously modulates frontal α power during a visuomotor task, promoting sustained cortical activation. This paradigm emerges as a sensitive tool for studying motor-cognitive coupling and may contribute to understanding MPH mechanisms in both healthy and clinical populations.