# [Expression of Concern] Insulin-dependent diabetes mellitus decreases osteoblastogenesis associated with the inhibition of Wnt signaling through increased expression of Sost and Dkk1 and inhibition of Akt activation

**Authors:** Mamiko Hie, Natsumi Iitsuka, Tomoyo Otsuka, Ikuyo Tsukamoto

PMC · DOI: 10.3892/ijmm.2026.5799 · International Journal of Molecular Medicine · 2026-03-16

## Full-text entities

- **Genes:** TRAP [NCBI Gene 100187907], DKK1 (dickkopf Wnt signaling pathway inhibitor 1) [NCBI Gene 22943] {aka DKK-1, SK}, AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207] {aka AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA}, IGF1 (insulin like growth factor 1) [NCBI Gene 3479] {aka IGF, IGF-I, IGFI, MGF}, SOST (sclerostin) [NCBI Gene 50964] {aka CDD, DAND6, SOST1, VBCH}
- **Diseases:** Insulin-dependent diabetes mellitus (MESH:D003922), Diabetes (MESH:D003920)

## Full text

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Source: https://tomesphere.com/paper/PMC13007994