# Primary dilated cardiomyopathy with LAMA2 and PKP4 mutations: imaging, genetics, and histology

**Authors:** Fang Zhou, Jinghui Li, Minjie Lu

PMC · DOI: 10.1093/ehjcr/ytag148 · European Heart Journal. Case Reports · 2026-03-05

## Full-text entities

- **Genes:** LAMA2 (laminin subunit alpha 2) [NCBI Gene 3908] {aka LAMM, MDC1A}, PKP4 (plakophilin 4) [NCBI Gene 8502] {aka p0071}
- **Diseases:** myocarditis (MESH:D009205), cardiogenic shock (MESH:D012770), atrial flutter (MESH:D001282), DCM (MESH:D002311), cardiomyopathies (MESH:D009202), supraventricular ectopy (MESH:D013617), cardiomyopathic (MESH:D044542), ischaemic (MESH:D018917), coronary artery disease (MESH:D003324), atrial electrical remodelling (MESH:D064752), mitral and tricuspid regurgitation (MESH:D014262), atrioventricular block (MESH:D054537), myocardial oedema (MESH:C536897), CMR (MESH:D006331), ventricular dysfunction (MESH:D018754), hypertrophy (MESH:D006984), Pulmonary hypertension (MESH:D006976), sore throat (MESH:D010612), fever (MESH:D005334), heart failure (MESH:D006333), mitral regurgitation (MESH:D008944), inflammatory (MESH:D007249), left ventricular hypokinesia (MESH:D018476), biventricular systolic dysfunction (MESH:D018487), arrhythmia (MESH:D001145), ventricular tachycardia (MESH:D017180), sudden cardiac death (MESH:D016757), atrial fibrillation (MESH:D001281), chest symptoms (MESH:D002637), coronary artery stenosis (MESH:D023921), motion (MESH:D009041), Chronic Diseases (MESH:D002908), premature ventricular contractions (MESH:D018879), ventricular ectopy (MESH:D050030), fibro-fatty replacement (MESH:D009810), fibrosis (MESH:D005355)
- **Chemicals:** gadolinium (MESH:D005682), natriuretic peptide (MESH:D045265)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** c.1141G > T, c.1637C > T, T-A-008

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Source: https://tomesphere.com/paper/PMC13007869