# The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles

## TL;DR

This paper explores how replacing parts of antimicrobial molecules with similar structures improves their effectiveness against drug-resistant bacteria.

## Contribution

The first systematic use of nonclassical bioisosteres in supramolecular self-associating amphiphiles to enhance antimicrobial activity.

## Key findings

- Bioisostere substitution improved antimicrobial efficacy against clinically relevant bacteria.
- The modification led to better antimicrobial activity across a range of supramolecular self-associating amphiphiles.

## Abstract

The rise of antimicrobial resistance (AMR) is one of the greatest health threats facing the world today. Supramolecular self-associating amphiphiles (SSAs) have shown potential for development as novel antimicrobial agents. We now move to explore the systematic use of nonclassical bioisosteres within these systems for the first time, reporting enhanced antimicrobial efficacy against a variety of clinically relevent bacteria as a result.

The use of bioisosteres enhances the antimicrobial activity for a range of supramolecular self-associating amphiphiles.