# Radiotherapy combined with immunotherapy achieves clinical complete response in elderly metastatic penile cancer: a case report

## TL;DR

An elderly patient with metastatic penile cancer achieved long-term remission using radiotherapy and immunotherapy, suggesting this combination could be effective for others.

## Contribution

This case report demonstrates a durable remission in elderly metastatic penile cancer using radiotherapy and Pembrolizumab.

## Key findings

- An 89-year-old patient achieved symptomatic relief and 38-month progression-free survival with radiotherapy and Pembrolizumab.
- The combination therapy may be effective for elderly patients who cannot tolerate chemotherapy.
- Further studies are needed to confirm the efficacy in more patients with metastatic penile squamous cell carcinoma.

## Abstract

A combination of local and systemic therapies is used to treat inguinal lymph node metastases post-penile cancer surgery. This multimodal approach may include surgery, chemotherapy, radiotherapy, and immunotherapy.

We describe an 89-year-old male with a history of penile cancer status post resection, who presented with multiple metastases to the left inguinal lymph nodes confirmed by pathological biopsy. The patient was treated with a combination of radiotherapy and Pembrolizumab. Following this combined modality therapy, he experienced symptomatic relief and achieved a progression-free survival exceeding 38 months.

This case suggests that concurrent radiotherapy plus Pembrolizumab may achieve durable remission in elderly, chemotherapy-intolerant, metastatic PSCC, but verification in more patients is needed.