# Adenoid ameloblastoma: Conservative approach in a rare odontogenic lesion

**Authors:** Eduardo dos Santos Vidal, William Cezar da Silveira, Camila Cerantula Moura, Hélen Kaline Farias Bezerra, Pablo Agustin Vargas, Juliana Lucena Schussel, Leandro Eduardo Klüppel, Heliton Gustavo de Lima

PMC · DOI: 10.1007/s10006-026-01547-3 · Oral and Maxillofacial Surgery · 2026-03-23

## TL;DR

This paper reports a rare case of adenoid ameloblastoma, a newly recognized dental tumor, and discusses its diagnosis and treatment.

## Contribution

The paper contributes a documented case of adenoid ameloblastoma to improve understanding and clinical management of this rare tumor.

## Key findings

- Adenoid ameloblastoma combines features of ameloblastoma and adenomatoid odontogenic tumor.
- Complete excision and cryotherapy were used in managing the tumor in a 32-year-old female.
- Clinical surveillance is crucial due to the potential for high recurrence rates.

## Abstract

Adenoid ameloblastoma (AA) is a newly recognized, rare odontogenic tumor variant, distinguished by histopathological features that combine characteristics of both ameloblastoma and adenomatoid odontogenic tumor.

A 32-year-old female with an unilocular radiolucent lesion in the mandible associated with the impacted third molar, diagnosed as AA. Surgical management included complete lesion excision and cryotherapy. Despite the absence of significant symptoms, clinical surveillance is essential, as AA may have high recurrence rates. The recent inclusion of this entity in the WHO Head and Neck Tumor Classification (2022) highlights the need for accurate diagnosis and appropriate interventions to optimize patient prognosis.

This report not only contributes to the growing understanding of this tumor biological behavior but also highlights the clinical relevance of documenting such cases to guide best practices and improve prognostic insights in rare odontogenic lesions.

The online version contains supplementary material available at 10.1007/s10006-026-01547-3.

## Linked entities

- **Diseases:** adenoid ameloblastoma (MONDO:0975925)

## Full-text entities

- **Genes:** KRT19 (keratin 19) [NCBI Gene 3880] {aka CK19, K19, K1CS}, CTNNB1 (catenin beta 1) [NCBI Gene 1499] {aka CTNNB, EVR7, MRD19, NEDSDV, armadillo}, KRAS (KRAS proto-oncogene, GTPase) [NCBI Gene 3845] {aka 'C-K-RAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A}, BRAF (B-Raf proto-oncogene, serine/threonine kinase) [NCBI Gene 673] {aka B-RAF1, B-raf, BRAF-1, BRAF1, NS7, RAFB1}, KRT14 (keratin 14) [NCBI Gene 3861] {aka CK14, EBS1, EBS1A, EBS1B, EBS1C, EBS1D}
- **Diseases:** odontogenic lesion (MESH:D009808), Tumor (MESH:D009369), swelling (MESH:D004487), odontogenic keratocyst (MESH:D009807), odontogenic epithelial tumors (MESH:C537961), AOT (MESH:C538229), DGCT (MESH:D018126), necrosis (MESH:D009336), obesity (MESH:D009765), hypothyroidism (MESH:D007037), paresthesia (MESH:D010292), AA (MESH:D000564), Head and Neck Tumor (MESH:D006258), osteolytic lesion (MESH:D030981), pain (MESH:D010146), dentigerous cyst (MESH:D003803)
- **Chemicals:** vancomycin (MESH:D014640), nitrogen (MESH:D009584), HE (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Mutations:** p.V600E

## Full text

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## Figures

6 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13006472/full.md

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Source: https://tomesphere.com/paper/PMC13006472