# Lung cancer masquerading in the background of bronchiectasis: a report of two cases and literature review

**Authors:** Jian Guo, Xiaoqian Shi, Wei Zhang, Xuewei Zhao, Xiaohui Lv, Bing Li

PMC · DOI: 10.3389/fonc.2026.1751661 · Frontiers in Oncology · 2026-03-09

## TL;DR

Two lung cancer cases were found in patients with bronchiectasis, highlighting the need for vigilance and regular imaging in such patients.

## Contribution

Reports two unique cases where lung cancer was incidentally found in bronchiectasis patients without typical diagnostic indicators.

## Key findings

- Lung cancer was identified through histopathology after surgery for bronchiectasis-related infections.
- No typical imaging or tumor marker signs were present in the cases.
- Regular imaging and timely surgical intervention are recommended for bronchiectasis patients.

## Abstract

We report two cases of lung cancer that were surgically resected from patients with underlying bronchiectasis. These cases are unique because the tumors were diagnosed neither through elevated tumor markers, hypermetabolism on PET-CT, nor the presence of typical malignant imaging features. Instead, they were incidentally identified through histopathological examination following lobectomy performed for recurrent bronchiectasis-related infections. We aim to enhance clinicians’ vigilance toward occult malignancies in patients with bronchiectasis by summarizing the treatment course of such concealed tumors. Bronchiectasis maybe associated with lung cancer. Implementing a regular imaging surveillance maybe necessary for these patients. Furthermore, timely surgical intervention should be considered when clinical or radiological findings raise suspicion of malignancy.

## Linked entities

- **Diseases:** lung cancer (MONDO:0005138), bronchiectasis (MONDO:0004822)

## Full-text entities

- **Diseases:** malignancies (MESH:D009369), infections (MESH:D007239), Lung cancer (MESH:D008175), Bronchiectasis (MESH:D001987)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13006225/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC13006225/full.md

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Source: https://tomesphere.com/paper/PMC13006225