# Gastric Neuroendocrine Tumor: A Report of a Rare Case

**Authors:** Emmanuel Mduma, Ndigwake E Mallango, Swafaa Z Abdallah, Andrew K Jackson, Elijah Ussiri

PMC · DOI: 10.7759/cureus.103901 · Cureus · 2026-02-19

## TL;DR

A rare case of a low-grade gastric neuroendocrine tumor is reported, highlighting the importance of accurate diagnosis and surgical treatment.

## Contribution

This paper presents a rare clinical case of a gastric neuroendocrine tumor and emphasizes the role of histopathology and surgery in its management.

## Key findings

- Histopathology and immunohistochemistry confirmed a WHO Grade 1 gastric neuroendocrine tumor.
- Surgical resection with clear margins resulted in an uneventful recovery.
- The case underscores the need for accurate diagnosis to distinguish gNETs from other gastric lesions.

## Abstract

Gastric neuroendocrine tumors (gNETs) are rare gastric neoplasms that often present with non-specific symptoms and may mimic other submucosal gastric lesions. We report a case of a WHO Grade 1 gastric neuroendocrine tumor in a 67-year-old male who presented with a 7-month history of epigastric pain, early satiety, and melena. Esophagogastroduodenoscopy revealed a broad-based ulcerated fundal mass, initially suspected to be a gastrointestinal stromal tumor. Histopathological examination with immunohistochemistry confirmed a well-differentiated neuroendocrine tumor with strong chromogranin A positivity. Contrast-enhanced computed tomography demonstrated a localized submucosal fundal lesion without nodal or distant metastasis. The patient underwent partial gastrectomy with complete excision of the tumor. Histology confirmed clear resection margins. The postoperative course was uneventful. This case emphasizes the diagnostic importance of histopathology and immunohistochemistry and supports surgical resection as effective treatment for localized, low-grade gastric neuroendocrine tumors.

## Linked entities

- **Diseases:** gastric neuroendocrine tumor (MONDO:0015062), gastrointestinal stromal tumor (MONDO:0011719)

## Full-text entities

- **Genes:** CHGA (chromogranin A) [NCBI Gene 1113] {aka CGA, PHE5, PHES}
- **Diseases:** tumor (MESH:D009369), submucosal gastric lesions (MESH:D013272), gastrointestinal stromal tumor (MESH:D046152), Gastric neuroendocrine tumors (MESH:D018358), epigastric pain (MESH:D010146), melena (MESH:D008551), gastric neoplasms (MESH:D013274)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13005446/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC13005446/full.md

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Source: https://tomesphere.com/paper/PMC13005446