# An ontology-based description of nano computed tomography measurements in electronic laboratory notebooks

**Authors:** F. Kirchner, D.C.F. Wieland, S. Irvine, S. Schimek, J. Reimers, R. Aversa, A. Boubnov, C. Lucas, S. Flenner, I. Greving, A. Lopes Marinho, T. M. Wong, R. Willumeit-Römer, C. Eschke, B. Zeller-Plumhoff

PMC · DOI: 10.1038/s41597-026-07052-2 · Scientific Data · 2026-03-19

## TL;DR

This paper introduces a system using semantic web technologies to ensure metadata from nano-computed tomography research is FAIR-compliant and easily accessible.

## Contribution

A new approach for creating FAIR metadata by integrating semantic annotation from the start of the research process using an electronic lab notebook.

## Key findings

- The Herbie platform enables automatic validation and semantic annotation of metadata during nano-computed tomography experiments.
- The system successfully captures complex instrument metadata and configurations in a user-friendly interface.
- SPARQL queries demonstrate effective data extraction from the generated knowledge graph.

## Abstract

Scientific communities have recognized the importance of well-documented metadata generated during research. However, ensuring that metadata is findable, accessible, interoperable, and reusable (FAIR) remains a significant challenge. To address this, scientific communities are working towards making metadata available in semantically annotated knowledge graphs using semantic web technologies. In our proposed solution, the creation of a schema is initiated at the very beginning of the scientific process. This is transformed into a data collection platform using the electronic laboratory notebook framework, Herbie, which facilitates the automatic validation and semantic annotation of metadata. Using the example of synchrotron-radiation-based nano-computed-tomography measurements at a beamline, we demonstrate this approach. It effectively captures the complex metadata of such research instruments along with their various configurations, providing a user-friendly experience. We illustrate how Herbie converts all semantic documents into a user interface, ensuring that the entered data automatically meets all FAIR requirements. Additionally, we show how data can be extracted from the knowledge graph using SPARQL queries.

## Full-text entities

- **Diseases:** ELNs (MESH:D007757), SHACL (MESH:D007806)
- **Chemicals:** magnesium (MESH:D008274), ELN (-), EtOH (MESH:D000431)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

11 figures with captions in the complete paper: https://tomesphere.com/paper/PMC13004976/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC13004976/full.md

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Source: https://tomesphere.com/paper/PMC13004976