Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease
Han Gao, Da Pan, Hélder A. Santos
TL;DR
This paper reviews how RNAi nanomedicine is transforming treatment for heart diseases by enabling precise gene regulation.
Contribution
The paper provides a comprehensive overview of RNAi nanotherapeutics for ischemic heart disease and outlines design principles for effective delivery systems.
Findings
RNAi nanomedicine enables tailored gene regulation for cardiac repair.
Key design principles for efficient delivery of RNAi therapeutics are identified.
Translational challenges and opportunities for RNAi in cardiovascular therapy are discussed.
Abstract
Ischemic heart disease (IHD) remains the foremost cause of mortality worldwide, characterized by extensive myocardial injury following infarction with limited regenerative capacity of the adult mammalian heart. RNA interference (RNAi) nanotechnology is revolutionizing cardiac therapy by leveraging the sequence‐oriented gene regulation that can overcome the obstacles hindering conventional therapeutic approaches. Here, we outline the evolving landscape of RNAi nanomedicine for cardiac repair, with an emphasis on therapeutic advances in myocardial infarction and atherosclerosis. We further discuss design considerations for constructing effective nanosystems, underscoring the critical principles by bridging mechanistic insights with material engineering. Finally, we delineate the translational pathway from bench to bedside, detailing current challenges and highlighting prospective…
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Taxonomy
TopicsRNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Graphene and Nanomaterials Applications