# A Comprehensive Analysis of the Blurring Boundary Between Cosmetic Applications and Medical Treatment

**Authors:** Eda Kumbasar‐Atay, Kadircan H. Keskinbora

PMC · DOI: 10.1111/jocd.70785 · 2026-03-19

## TL;DR

The line between cosmetic and medical dermatology is blurring, raising concerns about regulation, safety, and professional standards.

## Contribution

This paper systematically reviews the convergence of cosmetic and medical dermatology and its implications for regulation and patient safety.

## Key findings

- Dermatologic procedures like botulinum toxin and laser treatments are used both cosmetically and medically, creating regulatory ambiguity.
- Lack of a universal legal definition for 'cosmeceuticals' and off-label use of aesthetic technologies increase patient safety risks.
- Social media and aesthetic expectations are driving increased demand and complicating clinical decision-making.

## Abstract

Dermatology and cosmetology have traditionally been regarded as distinct disciplines, with dermatology focused on the diagnosis and treatment of disease and cosmetology aimed at enhancing aesthetic appearance. In recent years, this distinction has become increasingly blurred due to technological advancements, expanding clinical applications, regulatory gaps, and sociocultural influences.

This review aims to examine the factors contributing to the blurring boundary between cosmetic and medical dermatologic practices and to evaluate its regulatory, ethical, and patient safety implications.

A narrative review of peer‐reviewed literature, international regulatory frameworks, and professional guidelines was conducted. Dual‐use dermatologic interventions, including botulinum toxin, dermal fillers, and laser‐ and energy‐based devices, were analyzed across cosmetic and medical indications. Legal approaches in different jurisdictions and sociocultural drivers, such as social media–influenced aesthetic expectations, were also assessed.

The review demonstrates that many dermatologic procedures are positioned simultaneously as cosmetic and medical interventions, creating ambiguity in regulation and professional accountability. The absence of a universally accepted legal definition for “cosmeceuticals,” along with the expanding off‐label use of aesthetic technologies, contributes to inconsistent oversight and potential risks to patient safety. Increased patient demand driven by idealized aesthetic standards further complicates expectation management and clinical decision‐making.

The convergence of cosmetic and medical dermatology highlights the need for clearer legal definitions, strengthened regulatory frameworks, and well‐defined professional standards. A patient safety–centered approach, supported by improved public awareness and professional accountability, is essential to addressing the challenges associated with this blurred boundary.

## Full-text entities

- **Diseases:** cerebral palsy (MESH:D002547), BDD (MESH:D057215), warts (MESH:D014860), tenderness (MESH:D063806), muscle spasms (MESH:D013035), actinic keratoses (MESH:D055623), bruising (MESH:D003288), bruxism (MESH:D002012), hemangiomas (MESH:D006391), migraine (MESH:D008881), dystonia (MESH:D004421), hyperpigmentation (MESH:D017495), stroke (MESH:D020521), spider veins (MESH:D013684), cervical dystonia (MESH:D014103), muscle dysfunction (MESH:D009135), leg varicose veins (MESH:D014648), hemifacial microsomia (MESH:D006053), blepharospasm (MESH:D001764), skin cancers (MESH:D012878), lip deformities (MESH:D008047), erythema (MESH:D004890), rosacea (MESH:D012393), trauma (MESH:D014947), blindness (MESH:D001766), acne (MESH:D000152), Malignant melanoma (MESH:D008545), post (MESH:D000094025), infection (MESH:D007239), wine (MESH:D019339), headache (MESH:D006261), systemic diseases (MESH:D034721), seborrheic keratosis (MESH:D017492), psoriasis (MESH:D011565), social anxiety disorder (MESH:D000072861), edema (MESH:D004487), vascular occlusion (MESH:D008641), granuloma (MESH:D006099), neurological diseases (MESH:D020271), diseases of the skin, (MESH:D012871), pigmentary and vascular lesions (MESH:D014652), hypersensitivity (MESH:D004342), hypopigmentation (MESH:D017496), spasticity (MESH:D009128), granulomatous inflammation (MESH:D007249), basal cell carcinoma (MESH:D002280), congenital craniofacial abnormalities (MESH:D019465), ecchymosis (MESH:D004438), infectious diseases (MESH:D003141), burns (MESH:D002056), pain (MESH:D010146), hyperhidrosis (MESH:D006945), eczema (MESH:D004485), atrophic scars (MESH:D002921), vascular malformations (MESH:D054079), necrosis (MESH:D009336), anxiety disorder (MESH:D001008), embolic events (MESH:D004617), cutaneous lymphomas (MESH:D008223), dermatological diseases (MESH:D000168)
- **Chemicals:** growth hormones (MESH:D013006), acetylcholine (MESH:D000109), PLLA (MESH:C033616), AHAs (-), PMMA (MESH:D019904), HA (MESH:D006820), CaHA (MESH:D017886), CO2 (MESH:D002245)
- **Species:** Meleagris gallopavo (common turkey, species) [taxon 9103], Homo sapiens (human, species) [taxon 9606], Clostridium botulinum (species) [taxon 1491]

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Source: https://tomesphere.com/paper/PMC13003192