SARS-CoV-2 crossreactive B-cells outnumber seasonal coronavirus spike-specific clones at the end of the COVID-19 pandemic
Cristina Gonzalez-Lopez, Muriel Aguilar-Bretones, Julian Reinders, Jingshu Zhang, Petra van den Doel, Batuhan Bekki, Eric C. van Gorp, P. Hugo M. van der Kuy, Bart L. Haagmans, Corine H. GeurtsVanKessel, Marion P. G. Koopmans, Rory D. de Vries, Marit J. van Gils
TL;DR
The study found that SARS-CoV-2 immune responses at the end of the pandemic increased antibody levels against seasonal coronaviruses, especially OC43.
Contribution
The study reveals that SARS-CoV-2 immune responses can influence and enhance pre-existing immunity to seasonal coronaviruses.
Findings
End-pandemic individuals showed higher antibody levels against seasonal coronaviruses like OC43 due to cross-reactive SARS-CoV-2 responses.
Cross-reactive B-cell responses to SARS-CoV-2 contributed to OC43 neutralization.
Pre-pandemic individuals had negligible SARS-CoV-2 reactivity despite being seropositive for seasonal coronaviruses.
Abstract
How B-cell responses towards seasonal human coronaviruses (sHCoVs) impacted those towards SARS-CoV-2 has been widely studied, yet potential reverse effects are ill-defined. We compared sHCoV immune responses between cross-sectional pre-pandemic and end-pandemic cohorts of immunocompetent adults. We assessed Spike (S) reactive IgG and IgA serum and B-cell responses towards sHCoVs and dominant SARS-CoV-2 variants, and evaluated their contribution to OC43 neutralization. Pre-pandemic individuals were uniformly sHCoV IgG and IgA seropositive, yet SARS-CoV-2 S-reactivity was negligible. End-pandemic donors, had predominant SARS-CoV-2 responses that in part cross-reacted with sHCoV which accounted for higher serum NL63, HKU1 and OC43 antibody levels. This effect was strongest for OC43 S2 and this cross-reactive response contributed to OC43 serum neutralization. We conclude that…
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Taxonomy
TopicsSARS-CoV-2 and COVID-19 Research · Immune responses and vaccinations · vaccines and immunoinformatics approaches